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Information × Registration Number 0222U005008, 0119U002138 , R & D reports Title Application of the method of registration of spectral parameters of thin films (smears) of blood in the infrared range to determine individual sensitivity to drug treatment. popup.stage_title Head Sydorenko Mykhailo V., Registration Date 01-12-2022 Organization State Institution Department of Biotechnical Problems of Diagnostics of the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine popup.description2  As a result of the research, it was found that the developed technique allows recording the absorption spectra of thin films formed by drying smears of chemotherapy drugs: docetaxel, gemcitabine, carboplatin, paclitaxel, cisplatin, and fixing their interaction with albumin. Regardless of the structural formula of these drugs, this interaction is manifested by the appearance in the IR absorption spectra of films taken in the bands of Amide I, formed from an albumin solution with the addition of drugs, new peaks that are absent in the spectrum of the albumin solution and in the spectra of drug solutions. The spectral parameters of native blood smears, which, in our opinion, characterize the state of ligandization of albumin, a blood protein that performs a binding and transport function for various substances in the body, including drugs, are individual in cancer patients. they are significantly lower than in the group of practically healthy people, the lowest rates occur in patients with malignant diseases of the lung. In this group, the spectral indices in patients with lung squamous cell carcinoma are higher than in patients with adenocarcinoma. The analysis of the obtained results did not reveal any difference in the indices in patients with stages III and IV of the process. An increase in the spectral parameters of a native blood smear of cancer patients receiving chemotherapy after treatment with a solution of calcium chloride, in our opinion, characterizes the potential ability of albumin to additionally bind ligands, which can be considered as a favorable factor in individual sensitivity to chemotherapy. Product Description popup.authors Korytska Lidiia M. Levchenko Oleh Ye. Pershko Natalia Yu. Sydorenko Мykhailo V. popup.nrat_date 2022-12-01 Close