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Information × Registration Number 0222U005248, 0121U111946 , R & D reports Title Isoxazole-containing sulfanilamides as new biocidal agents with a broad spectrum of action: synthesis and biological evaluation popup.stage_title Head Pavliuk Oleksandr V., Registration Date 26-12-2022 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 Based on the obtained results of QSAR modeling, a number of potential biocides were selected for synthesis and further in vitro and in vivo investigation. The antimicrobial activity of promising sulfonamide derivatives of the isoxazole series with predicted high activity was determined by the disk diffusion method using the solid nutrient medium of Mueller-Hinton and Sabouraud against a number of standard and intra-hospital multi-resistant strains of gram-negative bacteria, such as Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii, and gram-positive bacterial strains of Staphylococcus aureus and clinical resistant isolates of C. krusei and C. glabrata fungi. In vivo testing of the acute toxicity of the studied derivatives of the isoxazole series was carried out according to the OECD protocol for the use of D. magna hydrobionts as a biomarker. The results of which proved the low toxicity and high antibacterial potential of almost all considered derivatives. The development of preparative methods of synthesis and preparation in the necessary quantities of target sulfonamides of the isoxazole series, in particular, using ring closing metathesis reaction, was continued. Product Description popup.authors Baran Maria M. Hodyna Diana M. popup.nrat_date 2022-12-26 Close