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Information × Registration Number 0222U005366, 0120U102660 , R & D reports Title Functional materials for biomedical purposes based on halogen-containing organic compounds popup.stage_title Head Semynozhenko Volodymyr P., Доктор фізико-математичних наук Registration Date 28-12-2022 Organization State Scientific Institution Scientific and Technological Complex" Institute of Single Crystals "of the National Academy of Sciences of Ukraine popup.description2 The purpose of work stage № 2: Identification and selection of the most promising compounds as components and starting substances of functional materials for medical and biological purposes by conducting an array of analytical, spectroscopic and physical studies of halogen-containing compounds. Studies of diesters of p-terphenyldicarboxylic acid showed that when halogen atoms are introduced into the alcohol residues of molecules of chiral diesters of p-TFDA, the higher investigated members of the homologous series of terphenyldicarboxylates have the highest known values of twisting ability in the inclined smectic mesophase and do not show negative effects in a practically significant range concentrations; in FELC, a significant dependence of the Kh on the helicoid pitch exists only for large pitches near the high-temperature phase transition, and at a distance from it, Kh is almost independent of the pitch in a wide range of its values. New iodinated heptamethine cyanine dyes were synthesized. Their spectroscopic and biological studies demonstrate an unexpected effect of increasing of the number of I atoms on the photodynamic destruction of cells of gram-positive and gram-negative microbial pathogens. Analysis of crystalline structures containing fluorenonophane and chlorine-derived solvent molecules suggests that halogen bonds are very weak intermolecular interactions, but their presence can affect the balance of intermolecular forces in the formation of supramolecular host-guest complexes. On the example of halogen-containing pyrrolyl acetic acid derivative, which is a structural analogue of the compound that showed antiviral activity, there were investigated and developed a strategy of the study of the effect of stressors on the qualitative and quantitative composition of synthetic substances. As a result of the work in 2020-2021, a patent application for an invention was filed, 17 articles and 6 abstracts in conference proceedings were published. Product Description popup.authors popup.nrat_date 2022-12-28 Close