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Information × Registration Number 0222U005373, 0122U001430 , R & D reports Title Study of regularities of development of endocrine disorders and concomitant diseases associated with normocalcemic disorders of parathyroid glands in persons affected by the Chornobyl NPP accident popup.stage_title Head Kaminskyi Oleksii V., Доктор медичних наук Registration Date 29-12-2022 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2  The incidence of thyroid disease in the Chornobyl NPP accident survivors in the presence of parathyroid hyperplasia was three times higher compared to the control group, namely hypothyroidism (27.3% and 10.5%, respectively) and nodular goiter (63.6% and 21.1%, respectively, p < 0.05). The incidence of normocalcemic hyperparathyroidism was 2.4% higher in survivors of the Chornobyl NPP accident with parathyroid hyperplasia than in the control group (18.2% and 15.8%, respectively) against the background of a higher level of parathyroid hormone. A retrospective analysis of the data indicated a high incidence of parathyroid hyperplasia among the irradiated population of Ukraine, including the exposed in low dose range. According to diagnostic ultrasound, the parathyroid hyperplasia was detected in 450 people (32.7 %) affevted as a result of the Chornobyl NPP accident, being 1.6 times more than in the control group, where this value was 20.7 % (р > 0.005). A high incidence of normocalcemic hyperparathyroidism was found among the Chornobyl NPP accident survivors and the control group (23.5% and 11.7%, p < 0.005). A trend to its increase over time was noted both in the Chornobyl NPP accident survivors and in non-exposed persons, namely since 2019 till 2022 the incidence increase was determined from 18.2 % and 10.4% to 26.4 % and 14.3 %, respectively. A stable significant relationship was established between the vitamin D intake and serum levels of ionized calcium and parathyroid hormone. Studies of vitamin D in blood serum of children born to irradiated parents and residents of radiation-contaminated territories showed its deficiency in 41.8 % vs 28.6 % in the comparison group, which may indicate the role of radiation factor in health state of the offspring. In these groups, the parathyroid hormone level remained within normal range (32.06 ± 2.96) ng/ml. Product Description popup.authors Afanasyev Dmytro E. Kaminskyi Oleksii V. Kopylova Olga V. Muraviova Iryna M. Chikalova Iryna G. popup.nrat_date 2022-12-29 Close