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Information × Registration Number 0223U000041, 0122U000863 , R & D reports Title Development of methods for the synthesis of carbenoid compounds of the series of imidazole and 1,2,4-triazole and their analogues. Study of biological properties popup.stage_title Head Korotkikh Mykola I., Доктор хімічних наук Registration Date 01-01-2023 Organization Institute of Physical and Organic Chemistry and Coal Chemistry. LM Litvinenko of the National Academy of Sciences of Ukraine popup.description2  Object of study. New carbene complexes of copper(I) and silver, antimicrobial properties. The purpose of the work is the synthesis of new copper(I) and silver carbene complexes, the study of their antimicrobial properties, and the search for pathways to synthesize chiral compounds based on carbenes. Research methods are synthetic, spectral (NMR spectroscopy), analytical (chromatographic, elemental analysis), computational (quantum chemical research), biological (antimicrobial studies). Results of research: The synthesis of carbene-phenanthroline complexes of copper(I) and silver was carried out, including fluorine-containing by the interaction of o-phenanthroline complexes of metals with azolium carbenoid salts in the presence of potassium carbonate. The thermal effects of the formation of dimers of fluorine-containing carbenes were calculated using the DFT method as a criterion for their stability. On four examples, the X-ray structures of carbene-phenanthroline complexes were determined, which turned out to be either ionic or polarized covalent. High antimicrobial activity of carbene-complex compounds was found, including fluorine-containing compounds, and the ionic carbene-phenanthroline complex of copper(I) iodide turned out to be the most active among the known copper(I) carbene complexes. Initial salt compounds for the synthesis of nucleophilic carbenes and chiral compounds were obtained. The field of application is the preparative synthesis of carbene complexes and their derivatives. Product Description popup.authors Yenya Vasyl І. Gvozdetska Viktoriya O. Gresko Sergii V. Doroshenko Tetyana F. Kompanets Mikhaylо О. Korotkikh Vladislav M. Nechitailov Maxim М. Popov Anatolii F. Rayenko Gennady F. Ustilko Yuliya O. popup.nrat_date 2023-01-01 Close