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Information × Registration Number 0223U000281, 0118U003121 , R & D reports Title Development of methods for asymmetric synthesis of compounds with potential biological activity popup.stage_title Head Kolodiazhnyi Oleg I., Доктор хімічних наук Registration Date 05-01-2023 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2  The project was dedicated to the development of methods of kinetic enzymatic deracemization and their application to obtain new biologically active compounds. Using enzymatic methods of separation of racemic indenols and subsequent functionalization of the synthesized enantiomerically pure compounds, indenol derivatives of a high degree of optical purity were obtained. Enzymatic deracemization of derivatives of dehydroindenols, dehydroindenidiols, vicinal cycloalkanes was carried out and new optically active substances were obtained. Synthesized enantiomerically pure (1S)- and (1R)-1-hydroxy- and 1-fluoroalkylphosphonates, which are convenient chiral synthetic blocks for obtaining new biologically active substances. Synthesized chiral phosphonobenzaldehydes, which are chiral reagents for obtaining phosphonic analogues of phosphotyrosine. Synthesized C-P analogs of phosphotyrosine as a representative of kinase enzymes that modify specific proteins by adding a phosphate group, in a process known as phosphorylation. The structure of the compounds was confirmed by NMR 1H, 19F, 13C, 31P spectra. A method of asymmetric oxidation of asymmetric sulfides using a chiral titanium tetraisopropoxide/tert-butylhydroperoxide/(S)- or (R)-binol complex was developed, which allows obtaining sulfoxides of all possible absolute configurations with a high enantiomeric excess. It has been proven that the use of (S)-Binol gives (R)-sulfoxide, and (R)-binol leads to the formation of (S)-sulfoxide. Product Description popup.authors Grishkun Evgeny V. Kibiryev Volodymyr K. Kolodiazhna Anastasiia O. Kolodiazhna Olga O. Osadchuk Tetiana V. Prisyajnyuk Dmitry V. Slastennikova Alyona O. Shejko Sergij Yu. popup.nrat_date 2023-01-05 Close