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Information × Registration Number 0223U000452, 0122U002081 , R & D reports Title Study of the reactive microenvironment as a factor in the progression of prostate cancer (2.2.5.453) popup.stage_title Head Zadvornyi Taras V., Кандидат біологічних наук Registration Date 07-01-2023 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2 A retrospective analysis of the immediate and long-term results of treatment of PCa patients was carried out, and a collection of tumor tissue samples from patients with different risks of cancer progression were selected. Small-sized corpora amylacea are also found in the tissue of patients with high risk of progression (by 1.4 times, p<0.05) compared to patients with a low progression degree. It was established that a characteristic feature of the tissue of the PCa patients with a high risk of disease progression is a significantly greater length (p<0.05) and width (p<0.05), as well as a lower density (p<0.05) of collagen fibers compared to neoplasms from patients with a low risk of tumor progression. During the histochemical study of the stromal component of tumors, it was established that in PCa patients with a high risk of disease progression, tumor microenvironment is characterized by a significantly higher number of mast cells (1.4 times, p<0.05), which are more often localized among malignantly transformed cells (in 2, 0 times, p<0.05) compared to patients with a low risk of progression. We analysed the features of the expression of the marker of tumor-associated fibroblasts - alpha-smooth muscle actin and established that level of its expression in the tissue of patients with a high progression risk (Me=23.10 a.u.) was 2.0 (p<0.05) times higher in comparison with the similar indicator in neoplasms of patients with a low progression risk (Me=11.73 a.u.). Product Description popup.authors Borikun Tetiana V. Timoshenko Аndriy V. Shcherbina Valeriia M. popup.nrat_date 2023-01-07 Close