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Information × Registration Number 0223U000488, 0121U111450 , R & D reports Title To develop a method for determining the magneto-optical properties of biogenic and synthetic functionalized iron-containing nanoparticles, suitable for the study of blood coagulation factors and fibrinolysis popup.stage_title Head Danysh Taras Vasylovych, Кандидат біологічних наукNovak Vasyl L., д.мед.н. Registration Date 09-01-2023 Organization State institution "Institute of blood pathology and transfusion medicine of Nataional Academy of Medical scinces of Ukraine" popup.description2  123 pp., 9 tables, 12 figures, 5 supplements, 103 citations. BIOGENIC AND SYNTHETIC MAGNETIC NANOPARTICLES, MAGNETO-OPTICAL ANALYSIS, FACTORS OF BLOOD COAGULATION AND FIBRINOLYSIS. The object of the study is the method of determining the dependent dynamic parameters of biogenic and synthesized iron-containing nanoparticles; processes of obtaining magnetic nanoparticles. The purpose of the work is to increase the accuracy of laboratory studies of blood coagulation factors and fibrinolysis using the developed magneto-optical method and the efficiency of the technology of obtaining them from blood plasma by using synthesized iron-containing nanoparticles. Research methods: magneto-optical analysis; chemical synthesis; magnetic separation; photometric; coagulological; statistical. The following scientific and practical results were obtained: a magneto-optical stand was created; a new, sensitive express test was developed for the quantitative analysis of biogenic magnetically dependent nanoparticles in biological fluids; experimentally confirmed its effectiveness for rapid testing of synthetic magnetic nanoparticles; original technologies for obtaining iron-containing nanoparticles were developed; the effect of synthesized nanoparticles on the activity of blood coagulation factors VIII and IX was investigated. Degree of implementation: acts of implementation, reports at international scientific forums, publications in scientific literature. Field of application: blood centers, chemical and pharmaceutical enterprises, research organizations. The implementation of research results will allow creating a new modern device for magneto-optical research of biogenic and synthetic magnetic nanoparticles, which will become the basis for the creation of diagnostic test systems in hematology and transfusiology. 17 scientific works were published, including 4 articles, 13 abstracts of reports, 6 in supplements to journals at international forums abroad, one patent. Product Description popup.authors Danysh Olha Yosifivna Danysh Taras V. Dovgan` Anatoly Petrovych Dulceva Natalia Anatolyivna Madych Sofiya Yevgenivna Novak Vasyl' L. Orlova Liubov Volodymyrivna Shurko Natalia Olehivna popup.nrat_date 2023-01-09 Close