Search academic texts

Information × Registration Number 0223U000706, 0119U102390 , R & D reports Title Experimental justification of the effectiveness of a new agent based on derivative dicarboxylic acid for the correction of functional and metabolic disorders of the liver and comorbid endocrine pathologies on the background of hepatitis popup.stage_title Head Kudria Mariia Ya., Кандидат біологічних наук Registration Date 19-01-2023 Organization State Institution “V.Ya.Danilevsky Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine” popup.description2 The composition and technology of a new potential combined medicinal product based on a camphoric acid derivative and a selenium-containing compound in the form of hard gelatin capsules have been theoretically and experimentally substantiated. Methods of quality control of the new drug have been developed, which will be included in the draft document "Methods of quality control of the medicinal product". The method of determining sodium selenite was validated, its specificity, correctness and precision were confirm.Models of subchronic tetrachloromethane- and paracetamol-induced hepatitis in male rats were reproduced to substantiate the effectiveness of a new cathazine-based agent for the correction of liver, thyroid gland, and spermatogenesis disorders. It has been established that the new product based on cathazine and selenium-containing compounds exhibits pronounced antioxidant activity, restores the pro-antioxidant balance in the liver and the body as a whole, increases the enzymatic activity of the liver, normalizes lipid metabolism, spermogram indicators, and contributes to the restoration of the thyroid condition. The economic effectiveness of the use of this agent in comorbid pathologies is shown.  Product Description popup.authors Belkina Inna O. Boyko Marina O. Burma Tetyana Yu. Vakula Volodymyr M. Varavin Vitaly P. Gavrish Tetyana S. Zavadska Natalya V. Kravchenko Svetlana V. Kustova Svetlana P. Matveeva Tetyana V. Melnikivska Natalya V. Nikishina Lyudmila Ye. Palagina Iryna A. Perets Olena V. Selyukova Natalya Yu. Sidorova Iryna V. Ustenko Nonna V. Chernyaeva Olena I. Cherniaieva Olena I. Yaremenko Fedir G. popup.nrat_date 2023-01-19 Close