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Registration Number

0223U000778, 0120U100753 , R & D reports

Title

Quantitative determination of dermal absorption in optimization of models of risk assessment of adverse effects of pesticides on workers

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Head

Kovalenko Vadym F., Кандидат біологічних наук

Registration Date

20-01-2023

Organization

Kundiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine

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 PESTICIDES, DERMAL ABSORPTION, HYGIENIC RATING, WORK AREA AIR, MATHEMATICAL MODELING, DERMAL EQUIVALENT OF PERMITTED EXPOSURE LEVEL, INHALATION EQUIVALENT OF PERMITTED EXPOSURE LEVEL, WORKING CONDITIONS, RISK ASSESSMENT The objects of the study are models for assessing the risk of adverse effects of pesticides on workers; complex absorbed dose; permissible internal dose; mass concentrations of active substances of pesticides in the air of the working area, on the skin and overalls of workers; professional risk assessment algorithm. The purpose of the work is scientific substantiation of measures to optimize exposure models for occupational risk assessment of pesticides through mathematical modeling of quantitative characteristics of the absorbed dose, harmonization of domestic and European methodological approaches to improving the practice of their safe use. Research methods – expert-analytical research of scientific information on the toxicological properties of the active substances of pesticides, study of the penetration of pesticides through the skin of test animals (rats) under conditions of single and long-term exposure in vivo and in vitro (alternative model using diffusion chambers), mathematical modeling ; natural hygiene experiment, prognostic risk assessment model. The subject of the study is mass concentrations of the pesticide acetamiprid in an experiment with application to isolated skin of rats, mass concentrations of active substances of pesticides in the objects of the production environment (air of the working area, washes from the skin surface of workers, patches on work clothes) according to the results of a natural hygiene experiment. The method is cost-effective, easily reproducible, which makes it possible to revise the standard in a fairly short period of time when new toxicological or epidemiological data on the pesticide appear.

Product Description

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Bronskova Tetiana I.
Demchenko Violetta F.
Dontsova Dariia O.
Zaiets Yeva R.
Kovalenko Vadim F.
Kofanov Valerii I.
Makarchuk Yaroslav V.
Pryhunova Viktoriia V.

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2023-01-20