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Information × Registration Number 0223U000854, 0119U003163 , R & D reports Title Explore the mechanisms of development and the course of the musculoskeletal infection with local administration of glucocorticoid drugs (experimental clinical research) popup.stage_title Head Grytsai Mykola Pavlovych, Доктор медичних наук Registration Date 20-01-2023 Organization SI “The Institute of Traumatology and Orthopedics by NAMS of Ukraine" popup.description2  The object of the study is fragments of affected and unchanged tissues of the knee joints from 82 rats, which under thiopental anesthesia were injected with a solution of HA (diprospan) or a suspension of bacterial bodies of pathogenic staphylococcus (108 in 1 ml) into the cavity of the knee joint, and clinical and anamnestic data of 56 patients with infectious complications (infectious processes in certain parts of the limbs and trunk) that developed after local administration of glucocorticoid drugs used in the treatment of rheumatological and/or degenerative-dystrophic lesions of the joints and para-articular tissues. Research methods are clinical, radiological, microbiological, immunological, biochemical and statistical. As a result of the work, it was found that the vast majority of patients who developed an infectious complication after the local application of glucocorticosteroids had a serious undercompensated concomitant pathology. The latter should be considered as a relative contraindication for the use of HA and as a risk factor for the occurrence of an infectious process. The occurrence of a septic process, as a rule, is due to the absence or inadequate diagnostic assessment before a local injection of the state of the tissues and the patient's body as a whole. Progression is due to the delay or complete lack of recognition and early purchase of the infection that started after the injection. Adherence to and implementation of indications and contraindications for intra-articular (local) injections of HA, principles of dosage, frequency of administration and time intervals between them are the basis and measures to prevent the occurrence and development of infectious complications arising after local administration of glucocorticoid drugs. Product Description popup.authors Gordiy Andriy Stepanovych Grygorovskyi Valeriy Volodymyrovych Hrytsai Mykola P. Dekhtiarenko Natalia Olexiivna Kolov Gennadiy Borisovich Kuzub Taisia Andriyvna Linenko Oleksandr Mykolajovych Liutko Olga Borysivna Magomedov Oleksandr Magomedovich Polischuk Larysa Vasylivna Polovynka Lidiia O. Sabadosh Vasul Ivanovuch Tsokalo Vasyl Mykolayovych Chalaydiuk Tetiana Petrivna popup.nrat_date 2023-01-20 Close