Search academic texts

Registration Number

0223U001024, 0117U006903 , R & D reports

Title

The research of the biological properties of microorganisms classified by the World Health Organization to the list of "priority pathogens" that are the most threatening human health and the development of means of combating them.

popup.stage_title

Head

Kovalchuk Valentyn , Доктор медичних наук

Registration Date

24-01-2023

Organization

Vinnytsia National Pirogov Memorial Medical University

popup.description2

 The etiological structure of purulent-inflammatory lesions, including among those injured in ATO/OS and patients with burn injuries, resistance of microorganisms to antibiotics, phenotypic mechanisms and genetic basis of such resistance was the subject of the study. The subject of the study was the sensitivity of selected pathogens to antiseptics and disinfectants of various chemical groups. Object of research: biological properties of bacteria of the genera Pseudomonas, Acinetobacter, Staphylococcus, Enterococcus. The goal of the NDR: to increase the effectiveness of the prevention and treatment of purulent-inflammatory diseases caused by microorganisms included by the WHO in the list of antibiotic-resistant "priority pathogens" that pose the greatest threat to human health. In order to achieve the goal, it was necessary to solve the following tasks: conduct a bacteriological study of material from wounded and burned patients in order to select, identify and accumulate the museum of relevant bacterial cultures in a quantity sufficient to solve the following tasks; determine the sensitivity of selected cultures to a wide range of antibiotics, antiseptics and disinfectants; to investigate the film-forming ability of selected cultures as one of the mechanisms of resistance to external chemical influences; to determine the presence of genetic determinants of resistance to various antibiotics in the accumulated bacteria strains; to investigate the rate of formation of resistance to antibiotics of bacterial strains with different genotypes; on the basis of the results of the study of the stability of selected strains of microorganisms, choose optimal compounds for the development of means of topical effect on pathogens in the wound; to experimentally substantiate the therapeutic effectiveness of the proposed recipes and methods of topical treatment of purulent-inflammatory processes.

Product Description

popup.authors

Ivanova Svitlana A
Babina Yuliana M
Babur Liudmyla
Bahniuk Nataliia Anatoliivna
Bebyk Vira Volodymyrivna
Burkot Vita Mychailivna
Vovk Iryna M
Honchar Oksana O
Gumenyuk Liliya Dmitrivna
Divinski Diana M
Denysko Tetiana Valeriivna
Dudar Alina Oksandrivna
Zhornjak Olena I
Kovalenko Iryna Mykolayvna
Kovalchuk Valentyn Petrovych
Kolodiy Svitlana A
Kondratiuk Viacheslav M
Kordon Yuliya V
Kryzhanovska Alla V
Kulyk Anna Volodymyrivna
Levchenko Bohdan Ihorovych
Makats Yevheniia Fedorivna
Melnychenko Mykola Volodymyrovych
Mrug Valentyna M
Nazarchuk Oleksandr Adamovych
Nastenko Volodymyr Borysovych
Osadchuk Neonila I
Prokopchuk Zoya Mykolaivna
Rymsha Elena V
Sidko Inna Yuriivna
Sorocoumova Ludmila K.
Stukan Oksana K
Sukmanska Hanna Dmytrivna
Tretjakov Maxim Sergijvich
Trofimenko Yuliia Y
Faustova Mariia O
Fomina Nadiia S
Tsyhanchuk Oksana P
Churakina Maryna V

popup.nrat_date

2023-01-24