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Information × Registration Number 0223U001024, 0117U006903 , R & D reports Title The research of the biological properties of microorganisms classified by the World Health Organization to the list of "priority pathogens" that are the most threatening human health and the development of means of combating them. popup.stage_title Head Kovalchuk Valentyn , Доктор медичних наук Registration Date 24-01-2023 Organization Vinnytsia National Pirogov Memorial Medical University popup.description2  The etiological structure of purulent-inflammatory lesions, including among those injured in ATO/OS and patients with burn injuries, resistance of microorganisms to antibiotics, phenotypic mechanisms and genetic basis of such resistance was the subject of the study. The subject of the study was the sensitivity of selected pathogens to antiseptics and disinfectants of various chemical groups. Object of research: biological properties of bacteria of the genera Pseudomonas, Acinetobacter, Staphylococcus, Enterococcus. The goal of the NDR: to increase the effectiveness of the prevention and treatment of purulent-inflammatory diseases caused by microorganisms included by the WHO in the list of antibiotic-resistant "priority pathogens" that pose the greatest threat to human health. In order to achieve the goal, it was necessary to solve the following tasks: conduct a bacteriological study of material from wounded and burned patients in order to select, identify and accumulate the museum of relevant bacterial cultures in a quantity sufficient to solve the following tasks; determine the sensitivity of selected cultures to a wide range of antibiotics, antiseptics and disinfectants; to investigate the film-forming ability of selected cultures as one of the mechanisms of resistance to external chemical influences; to determine the presence of genetic determinants of resistance to various antibiotics in the accumulated bacteria strains; to investigate the rate of formation of resistance to antibiotics of bacterial strains with different genotypes; on the basis of the results of the study of the stability of selected strains of microorganisms, choose optimal compounds for the development of means of topical effect on pathogens in the wound; to experimentally substantiate the therapeutic effectiveness of the proposed recipes and methods of topical treatment of purulent-inflammatory processes. Product Description popup.authors Ivanova Svitlana A Babina Yuliana M Babur Liudmyla Bahniuk Nataliia Anatoliivna Bebyk Vira Volodymyrivna Burkot Vita Mychailivna Vovk Iryna M Honchar Oksana O Gumenyuk Liliya Dmitrivna Divinski Diana M Denysko Tetiana Valeriivna Dudar Alina Oksandrivna Zhornjak Olena I Kovalenko Iryna Mykolayvna Kovalchuk Valentyn Petrovych Kolodiy Svitlana A Kondratiuk Viacheslav M Kordon Yuliya V Kryzhanovska Alla V Kulyk Anna Volodymyrivna Levchenko Bohdan Ihorovych Makats Yevheniia Fedorivna Melnychenko Mykola Volodymyrovych Mrug Valentyna M Nazarchuk Oleksandr Adamovych Nastenko Volodymyr Borysovych Osadchuk Neonila I Prokopchuk Zoya Mykolaivna Rymsha Elena V Sidko Inna Yuriivna Sorocoumova Ludmila K. Stukan Oksana K Sukmanska Hanna Dmytrivna Tretjakov Maxim Sergijvich Trofimenko Yuliia Y Faustova Mariia O Fomina Nadiia S Tsyhanchuk Oksana P Churakina Maryna V popup.nrat_date 2023-01-24 Close