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Registration Number

0223U001093, 0119U102335 , R & D reports

Title

To determine the complex of phenotypic and molecular genetic characteristics of strains of staphylococci isolated from patients with chronic dermatoses, and to develop approaches to the treatment of these diseases

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Head

Kutasevych Yanina F., Доктор медичних наук

Registration Date

25-01-2023

Organization

State institution "Institute of Dermatology and Venereology of NAMS of Ukraine"

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The object of the study: chronic dermatoses, reference and staphylococcal strains removed from patients and practically healthy individuals, phenotypic and molecular genetic characteristics of autostrains of staphylococci, immunological and biochemical indicators of patients. The purpose of the study was: to increase the efficiency of diagnosis and treatment of chronic dermatoses based on the detection of immunological parameters of patients and a complex of phenotypic and population characteristics of strains of the pathogen, which are associated with different severity of the course of the disease. Research methods: analytical, general clinical, bacteriological, immunological, molecular genetic, biochemical, statistical. The clinical and anamnestic features of the course of chronic dermatoses and the microbiocenoses of the skin and upper respiratory tract of patients were studied, with the determination of the spread of staphylococci and levels of sensitivity to antibacterial drugs; the complex of pathogenicity factors of staphylococcal strains isolated from patients with widespread dermatoses was investigated, with the provision of a comprehensive assessment of the indicators of persistence and aggression of the extracted staphylococcal strains; the study of phenotypic features of clinical strains of S. aureus, with determination of their genetic variability and influence on indicators of non-specific resistance and specific humoral response of the macroorganism. The laboratory and clinical effectiveness of an ointment containing 2% mupirocin and an antibacterial drug of systemic action containing linezolid, which are recommended for the treatment of infectious and inflammatory complications of common dermatoses, were studied. An algorithm for predicting the severity of the course of allergic dermatoses has been developed. The clinical effectiveness of use of a drug containing linezolid for the treatment of severe pyoderma as a reserve antibiotic has been proven.

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Babuta Anastasiia R.
Holub Hanna P.
Holubko Serhii P.
Goncharenko Valentyna V.
Dzhoraieva Svitlana K.
Levytska Olena V.
Miliutina Olena Y.
Matiushenko Valeriia P.
Mashtakova Iryna O.
Oliinyk Iryna O.
Oliinyk Olha I.
Pokhyl Serhii I.
Puhachova Oksana V.
Savoskina Vikroriia O.
Sokol Oksana A.
Soloshenko Elvira M.
Stulii Olha M.
Tsymbal Viktoriia M.
Shevchenko Zoia M.
Shchoholeva Olena V.
Yukhymchuk Yevhenii V.
Yarmak Tetiana P.