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Information × Registration Number 0223U001189, 0118U001043 , R & D reports Title The establishment of morphological changes in the formation of the central nervous system of man during the prenatal period of ontogenesis (macroscopic, histological, morphometric and immunohistochemical research) popup.stage_title Head Shkolnikov Volodymyr S., Registration Date 25-01-2023 Organization Vinnytsia National Pirogov Memorial Medical University popup.description2 For the first time, the features of the size of the basal and wing-shaped plates and the relationships of the nerve tube layers of the rhomboid brain in human embryos for 6-7 weeks are established. pre -natal development. The chronology of changes in the macrometric parameters of the medulla oblongata in human fruits during the prenatal period of ontogeny and periods of accelerated growth rate of medulla oblongata in the prenatal period of human development was established. For the first time the age peculiarities of the cellular composition of the ependymal layer of the fourth ventricle were established, a morphometric study of this layer was performed and the patterns of its structure in embryos and human fruits were revealed. For the first time, the morphology of radial glya in the medulla oblongata and the features of its age -related changes during the prenatal period of human ontogeny were established. For the first time, the patterns of change of the area of nuclei, neuroblasts and nuclei of the medulla oblongata in the embryos and human fruits, their pace of intense and slow growth, and their asynchronous nature of changes during the intrauterine period of development have been revealed. Also, for the first time the features and structure of neuroblasts of the nuclei of the medulla oblongata and determining the patterns of their changes in fruits of different gestational age were investigated. The revealed morphological changes of nerve cells during prenatal ontogeny deepen the idea of their differentiation. For the first time the patterns of expression of immunohistochemical markers of Vymenin, S-100, synaptophysicine, KI-67, BCL-2 in the structures of the medulla oblongata in embryos and fruits of human of different gestational age were revealed. For the first time, organo-, histo- and cytometric parameters and features of the structure of the medulla oblongata in human fruits with malformations. Product Description popup.authors Hryshchenko Yuliya Vadymivna Zalevskyi Leonid Leonidovych Lopatkina Oksana Pavlivna Prykhodko Svitlana Oleksandrivna Rutska Iryna Anatoliyivna Stelmashchuk Pavlo Olehovych Shkolnikov Volodymyr S. popup.nrat_date 2023-01-25 Close