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Registration Number

0223U001248, 0122U001818 , R & D reports

Title

Hybrid nanosystems based on "smart" polymers for biotechnology and medicine

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Head

Kutsevol Nataliia V., Доктор хімічних наук

Registration Date

26-01-2023

Organization

Taras Shevchenko National University of Kyiv

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The object of research is multi-component nanosystems based on "smart" polymers and hydrogel materials with incorporated biologically active nanoparticles of metals, metal oxides, and drugs. The purpose of the work is to create highly effective polymer-based nanosystems for minimally invasive methods in oncology; hydrogel materials with high antibacterial activity for the treatment of wounds of various genesis; as well as highly sensitive nanocomposites for new imaging methods in biotechnology and medicine. Research methods – gel permeation chromatography, transmission electron (TEM) and scanning microscopy (SEM), dynamic light scattering (DLS), NMR, UV-spec. and IR spectroscopy, photoluminescence, in vitro and in vivo testing. Dextran-polyacrylamide (DPAA) copolymers in nonionic and anionic forms and heat-sensitive polymer dextran-poly-isopropylacrylamide (D-PNIPAM) were synthesized and characterized. Binary nanosystems were synthesized and studied in polymer matrices with incorporated nanoparticles of Au, Ag, ZnO and drugs. It was established that nanocomposites with anticancer drugs showed high efficiency in comparison with free anticancer drugs. Hydrogels based on Dextran-Polyacrylamide and Chitosan-Polyacrylamide graft copolymers were synthesized and studied, differences in the physicochemical characteristics of synthesized hydrogels and composites based on them were established. It has been proven that nanocomposite hydrogels with AgNPs and drugs have higher antibacterial activity than classical antiseptics. A series of new photosensitive model compounds, which may be promising for biomedical applications, have been synthesized and studied. 

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Yeshchenko Oleh А.
Virych Pavlo A.
Kuziv Yuliya I.
Nadtoka Oksana M.
Pavlenko Vadym O.
Smokal Vitalii O.
Kharchenko Oksana H.
Chumachenko Vasyl A.