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Information × Registration Number 0223U001499, 0120U100668 , R & D reports Title The role of mononuclear phagocytes virus-mediated activation in multiple sclerosis popup.stage_title Head Kolyada Tatiana I., Доктор медичних наук Registration Date 30-01-2023 Organization State Institution "I.Mechnikov Institute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine" popup.description2 The relationship between a high level of EBV and HHV-6 antigenic load and a progressive type of the course of the disease was revealed. The EDSS disability score in HHV-6-seropositive patients with MS was significantly higher compared to seronegative patients. A comparative description of the effect of TLR agonists, in particular the HERV-W-ENV glycoprotein, on subpopulation-dependent functional properties of monocytes (nitric oxide production; arginase activity; cytokinesis, antigen-presenting molecules, phagocytosis) in patients with various types of MS is given. With a progressive type of course, induction of HERV-W-ENV leads to an imbalance in the production of both pro-inflammatory and regulatory cytokines, as well as cosignal molecules. It has been confirmed that HERV-W-ENV can activate the innate immune system through a TLR4/CD14-dependent pathway and promotes the development of a Th1-type immune response. Due to its pro-inflammatory properties, HERV-W protein may be involved in immunopathological cascades associated with chronic inflammatory and/or neurodegenerative diseases, and MS.The dependence of functional state of monocytic phagocytes peripheral blood on the form of the clinical course of the disease was confirmed on the model of TLR-dependent activation in vitro Product Description popup.authors Vdovochenko Natali I. Kolyada Tetyana I. Makijenko Tetyana Skliar Anatolii I. Tupotilov Olexandr V. popup.nrat_date 2023-01-30 Close