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Information × Registration Number 0223U001707, 0122U001561 , R & D reports Title Development of a multisensory system based on a highly efficient recombination transducer for liquid analytes and metabolite screening popup.stage_title Head Lytvynenko Serhii V., Кандидат фізико-математичних наук Registration Date 01-02-2023 Organization Taras Shevchenko National University of Kyiv popup.description2 Research object: single and multi-sensor silicon sensor structures of the recombination type with modified interfaces; functional lighting devices for generating an informative signal, variation of experimental conditions, addressing; biological substances intended for the establishment of the electronic tongue system, which act as markers of the functional state of the organism. The purpose of the work: development and testing of mathematical models describing the operation of the recombination sensor; active prototypes of structures that transform information of enzymatic reactions. Research methods: photoelectric and electrophysical methods, the method of preparative biochemistry, biochemical methods of determining enzymatic activity (Reitman-Frenkel method), numerical modeling methods. Physical quantitative and qualitative models have been created that describe the operation of the recombination sensor. For the first time, using a self-consistent approach (Poisson's equation in the OPZ and Shockley-Reed recombination statistics), fundamental results were obtained that allow us to obtain the dependence of the photocurrent on the surface properties under the conditions of contact with the analyte and to theoretically consider the peculiarities of the functioning of the photoelectric transducer. The characteristics of the conversion under conditions of different modulation frequencies and different levels of injection are determined. The physical principles and experimental means of "smart" functional illumination of sensor structures were developed and the operation of the sensor platform was tested. The possibility of using a recombination sensor to detect biochemical markers was demonstrated for the first time in the experiments on the detection of ATP hydrolase activities in preparations of suspension of PM erythrocytes of rats. Product Description popup.authors Bunak Sergiy V. Zaderko Olexander М. Kozynez Oleksiy V. Skryshevsky Valeriy A. Sus' Bogdan B. Tsymbaliuk Olha V. popup.nrat_date 2023-02-01 Close