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Information × Registration Number 0223U001767, 0122U000392 , R & D reports Title To develop the individualized weight loss programs in patients with different cardiovascular risks based on the study of genetic factors and markers of inflammation popup.stage_title Head Isayeva Ganna Serhiivna., Доктор медичних наук Registration Date 03-02-2023 Organization Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine" popup.description2 The study of 87 patients aged 20 to 75 years with high and very high cardiovascular risk(CVR). Blood pressure (BP) was measured for patients, BP was monitored daily, body weight, body mass index, height, the ratio of fat and muscle tissue was assessed, the risk of developing type 2 diabetes was assessed using the FINDRISK scale, CVR assessment was conducted according to the scales: to the SCORE and to the Framingham, the International Long-Term Physical Activity Questionnaire (IPAQ) was used to assess physical activity. The biochemical parameters were evaluated, polymorphisms in PPARG2, ADRB2, ADRB3, FABP2 genes were determined by real-time polymerase chain reaction. It was established that early detection of carriers of polymorphic variants CG/СG+GG PPARG2(Pro12Ala, rs1801282), AA/AA+AG ADRB2(Arg16Gly, rs1042713) and TT ADRB3(Trp64Arg, rs4994) allows for the development of individualized preventive programs based on diet modification and selection physical load. The relationship between the carrier of polymorphic variants of PPARG2, ADRB2, ADRB3, FABP2 genes and changes in weight has not been established. It has been proven that total sitting time is an independent factor of negative impact on blood lipids. Being in a sitting position for more than 8 hours a day cancels out the positive effects of physical activity for 1.5 hours 2 times a week. People with a high level of stress have a low adherence to treatment. Insomnia and circadian disturbances of sleep and alertness have been found to be the most common sleep disturbances in patients at high and very high CVR. A significant decrease in the quality of life index was noted from 69.7% to 43.2% in patients with high and very high cardiovascular risk after 8 months of observation. Inflammatory and destructive lesions of the periodontium caused by the microflora of the oral cavity were diagnosed in the majority of patients of the main group. Product Description popup.authors Buriakovska Olena Valentinova Inna Vovchenko Maryna Volobuieva Vira Emelyanova Natalia Yu. Karlashova Taisiia Komir Iryna Kostiuk Olena Peteneva Larysa Sydora Inna Shalimova Anna Serhiivna Shut Inna popup.nrat_date 2023-02-03 Close