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Information × Registration Number 0223U001769, 0120U000067 , R & D reports Title To determine the influence of genetic and epigenetic factors on the development of premature aging in metabolic-associated diseases and to develop personalized approaches to their prevention popup.stage_title Head Колеснікова Олена Вадимівна, Registration Date 03-02-2023 Organization Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine" popup.description2 The object of the study: patients of different age groups (25-44 years, 45-60 years, 61-75 years and over 75 years), who have a moderate risk of developing cardiovascular diseases in combination with the risk and presence of metabolic associated diseases (MAD) and individuals of the control group. Methods: detection of polymorphic variants of superoxide dismutase (SOD2, rs4880), catalase (CAT, rs1001179), sirtuin (SIRT1, rs7069102) genes; evaluation of the influence of epigenetic factors (telomere length, telomerase activity, DNA methylation, sirtuin-1 (SIRT1)), calculation of biological age according to the PhenoAge DNAm epigenetic clock, determination of metabolic and oxidative status, analysis of body composition and distribution of adipose tissue by the bioimpedance method, questionnaires. А scientifically substantiated concept of the relationship between premature aging and the development of MAD was developed. Based on the epigenetic age calculated using PhenoAge and the logistic regression analysis, it was determined that glycated hemoglobin, sirtuin-1, leukocyte telomere length, total cholesterol and the insulin resistance index are associated with premature ageing. A method of determining biological age and the rate of aging has been developed (patent application No. a2021 07048 dated 09.12.2021), the use of which when conducting screening studies of the population in programs of primary and secondary prevention of chronic and age-related diseases allows to identify groups of people at increased risk for timely medication and non-pharmacological intervention. The prognostic significance of genetic and epigenetic markers for ageing rates and the formation of various phenotypes of MAD was established, which was used to develop an algorithm for diagnosing premature ageing and personalized approaches to the prevention of MAD, taking into account metabolic status, genetic and epigenetic markers of biological age. Product Description popup.authors Bondar Tetiana Dudar Larysa O. Zaprovalna Olga Yevgenievna Kostiuk Olena Lavrenko Tetiana A. Otchenashenko Olena O. Potapenko Anna Vasylivna Radchenko Anastasiia O. Chenchik Tetyana Shut Inna popup.nrat_date 2023-02-03 Close