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Registration Number

0223U001860, 0119U102309 , R & D reports

Title

Optimization of complex methods of treatment of patients with onychomycosis with absolute and relative contraindications to systemic antifungal therapy

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Head

Kutasevych Yanina F., Доктор медичних наук

Registration Date

03-02-2023

Organization

SE "Institute of Dermatology and Venereology of NAMS of Ukraine"

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 Research object: onychomycosis, nail plates, blood. The aim of the work was to increase the effectiveness of treatment of patients with onychomycosis by optimizing methods of diagnosis, complex differential therapy, assessment of curability and clinical significance of concomitant pathology, presence of absolute and relative contraindications to systemic antifungal therapy. Methods: clinical, biochemical, immunoenzymatic, microbiological, molecular genetic, instrumental, statistical. A complex method of treatment of patients with onychomycosis with absolute contraindications to systemic antimycotics using topical antimycotics and agents has been developed, which allows to achieve clinical and mycological recovery in 72.7% of patients. A differentiated approach to the treatment of patients with onychomycosis with contraindications to systemic antimycotics is scientifically justified, which allowed to achieve clinical and mycological recovery in 90.8%. It has been proven that in patients with onychomycosis, it is necessary to monitor cytolysis enzymes, urea during long-term treatment with systemic antifungals and use hepatoprotectors. It was established that the use of infrared thermography confirms the violation of blood circulation, which justifies the appointment of vascular drugs and can be used to control temperature fields in the process of sanogenesis. The detection of specific Ig E makes it possible to assess allergy to certain mushroom allergens and to predict the development of allergic reactions. The algorithm for examining patients with onychomycosis after treatment has been improved in order to establish the viability of fungi and monitor recovery.

Product Description

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Yereshchenko Olena O.
Abdalla Aliia E.
Azimova Hanna O.
Holub Hanna P.
Kondakova Hanna K.
Kutasevych Yanina F.
Levytska Olena V.
Miliutina Olena Y.
Mashtakova Iryna O.
Oliinyk Iryna O.
Oliynyk Hryhoryi A.
Oliinyk Olha I.
Semko Halyna O.
Sokol Oksana A.
Soloshenko Elvira M.
Stulii Olha M.
Suprun Kseniia H.
Tsymbal Viktoriia M.
Shevchenko Zoia M.
Yukhymchuk Yevhenii V.
Yarmak Tetiana P.

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2023-02-03