Search academic texts

Information × Registration Number 0223U002038, 0119U102449 , R & D reports Title Experimental study of bone tissue reaction and biomechanical properties of "implant-bone"system at application of innovative 3D-printed materials made of polilactide acid and trabecular titanium popup.stage_title Head Korzh Mykola O., Доктор медичних наук Registration Date 07-02-2023 Organization State institution "Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine" popup.description2 Object: Bone regeneration at implantation of 3D-printed materials from polylactic acid (PLA) and trabecular titanium (TT). Purpose: To investigate the morphological and functional features of bone tissue in an experiment on animals and to study the biomechanical properties of the "implant-bone" system in the case of using 3D-printed implants made of polylactic acid and trabecular titanium and to perform its clinical implementation. Research methods and equipment: histological, biochemical, biomechanical, mathematical modeling, clinical, radiological, statistical. Theoretical and practical results: In experiment on rats, it was established that PLA is biocompatible and processes high osteointegrative qualities. It was proved on the mathematical model of the proximal humerus fracture what is fixed with a plate that the introduction of 3D implants printed from PLA as a reinforcing material allows to reduce stress in the metal structure. It was determined that among titanium 3D implants with different surface structures, the best osseointegration indicators were obtained in the case of using TT, which is similar to porous tantalum. Clinical approval demonstrated the effectiveness of using 3D implants made of PLA and titanium powder in patients with osteoporosis and osteopenia. Novelty: New scientific knowledge was obtained about the osseointegration of innovative 3D-printed implant materials from PLA and TT; a porous biodegradable implant and a reversible total modular shoulder endoprosthesis were proposed for clinical implementation. Effectiveness of implementation: The obtained results can be used for further scientific research and can improve the results of treatment in patients with proximal humerus fractures with osteoporosis and osteopenia. The developed 3D implants are promising material for replacing of bone defects, treating fractures and injuries of the musculoskeletal system caused by war injuries. Scope of use: Medicine. Product Description popup.authors Ashukina Nataliіa Oleksandrivna Korzh Mykola Oleksiiovych Leontieva Fryda Solomonivna Makarov Vasyl Borysovych Mezentsev Volodymyr Oleksiiovych Morozenko Dmytro Volodymyrovych Nikolchenko Olha Anatoliivna Pidhaiska Olha Oleksiivna Poplavska Karolina Serhiivna Subbota Ihor Anatoliiovych Tankut Oleksii Volodymyrovych Filipenko Volodymyr Akimovych popup.nrat_date 2023-02-07 Close