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Information × Registration Number 0223U002084, 0122U001962 , R & D reports Title Natural biomolecules and their analogues are the basis for creating molecular ensembles to solve problems of chemistry, medicine and agrochemistry popup.stage_title Head Khylia Volodymyr P., Доктор хімічних наук Registration Date 08-02-2023 Organization Taras Shevchenko National University of Kyiv popup.description2 Object of research – oxygen-containing and nitrogen-containing natural compounds (alkaloids, terpenoids, (iso)flavones, 2(3)-hetarylchromones, 3(4)- arylcoumarins, 3(4)-arylisocoumarins, dihydro(iso)coumarins, furocoumarins, pyranocoumarins, isoxazoles, pyrazoles, azepinones, pyrimidines, (iso)quinolines), spirocyclic compounds and their isosteric analogues, including sulfonyl halides, fluoro-, phosphorus-containing and amino acid derivatives. Aim of work – design and development of optimal preparative methods for the synthesis of natural bioheterocycles and their synthetic derivatives - oxygen-containing and nitrogen-containing natural compounds and alkaloids (flavones, isoflavones, 3- arylcoumarins, 4-arylcoumarins, 3-arylisocoumarins, 4-arylisocoumarins, dihydro- (iso)coumarins, furocoumarins, pyranocoumarins, isoxazoles, pyrazoles, azepinones, pyrimidines, (iso)quinolines), terpenoids, spirocyclic compounds and their isosteric analogues, including sulfonyl halides, fluoro-, phosphorus-containing and amino acid derivatives. Methods of research – methods of target-oriented (TOS) and lead-oriented synthesis (LOS); synthesis under high pressure, in an inert atmosphere; NMR spectroscopy, chromatography-mass spectrometry, elemental and X-ray structural analysis; in vitro and in vivo studies. As a result of the work, an analysis of literature data on the synthesis and properties of oxygen-containing and nitrogen-containing heterocycles, in particular functionalized isoflavones, isocoumarins, isoquinolinones, pyrimidines and saturated boron derivatives, was carried out. Methods for the synthesis of new oxygen-containing compounds, including (iso)flavones, 2(3)-hetarylchromones, 3(4)-aryl(iso)coumarins, 3(4)-dihydro(iso)coumarins, furocoumarins, pyranocoumarins and their functionalized derivatives, in particular spirocyclic and isosteric analogues, sulfonyl halides, fluoro-, phosphorus-containing and amino acid derivatives. Product Description popup.authors Blahun Oleksandr P. Veselsky Stanislav P. Glibov Evgen K. Hryhorenko Oleksandr О. Zhersh Serhii A. Moskvina Viktoria S. Shablykina Olga V. Schokol Tetyana V. Shtanova Lidiya Ya. popup.nrat_date 2023-02-08 Close