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Information × Registration Number 0223U002127, 0121U113840 , R & D reports Title Study of the lactobacilli, bifidobacteria and opportunistic pathogens of the human microbiota influence on the features of mechanisms realization of metabolic disturbances in the tumor process (2.2.5.447) popup.stage_title Head Lykhova Oleksandra O., Кандидат біологічних наукChekhun Vasyl F., Доктор медичних наук Registration Date 10-02-2023 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  The direct interaction of live bacterial cells of Bifidobacterium animalis or Lactobacillus rhamnosus species and breast cancer cells has the most significant effect on the viability of malignant cells, compared to their non-contact co-cultivation or pasteurized microorganisms. Cells of the luminal subtype, especially MCF-7 cells, are more sensitive to the effects of Bifidobacterium animalis and Lactobacillus rhamnosus than cells of the basal subtype. Co-cultivation of malignant cells with Bifidobacterium animalis leads to activation of apoptosis in breast cancer cells by mitochondrial p53-dependent pathway in MCF-7 cells and p53-independent pathway in MDA-MB-231 cells. Cdk inhibitor p21WAF1 plays a key regulatory role as a switch of apoptotic processes in MDA-MB-231 cells. Product Description popup.authors Borikun Tetiana V. Todor Igor M. Chumak Alina V. Shvets Yuliya V. Shvets Yuliya V. popup.nrat_date 2023-02-10 Close