Search academic texts

Information × Registration Number 0223U002209, 0121U113839 , R & D reports Title Medical sorbents and nanomaterials in experimental therapy of systemic manifestations of cytostatic disease (2.2.5.446) popup.stage_title Head Nikolaiev Volodymyr Н., Доктор медичних наук Registration Date 12-02-2023 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  A working fraction of a granulated highly active carbon sorbent was obtained from carbonized nitrogen-containing resin VP-1AP with a bulk mass of 0.09 g/cm3 and a volume of sorption pores, Vs = 2.12 cm3/g, determined by benzene. Fractions of carbon sorbent powder with a homogeneous size distribution in the submicron spectrum were obtained at the grinding unit. A negative influence of doxorubicin on the hemoglobin level, number of erythrocytes, leukocytes, myeloid and erythroid cells (MEC) of the bone marrow, as well as on some biochemical parameters of animals blood was established. As a result of the administration of Dox in rats in a cumulative dose of 26.0 mg/kg, almost 5-fold increasing the level of creatine phosphokinase (CPK) and a 4-fold increasing of troponin concentration was observed. It has been shown that the daily intake of granular highly active carbon enterosorbent within a month in a dose of 1.5 cm3 helps to reduce the intensity of general toxic and inflammatory-dystrophic processes in the body of rats with EDID, mitigates the manifestations of the heart, liver and kidneys disfunctions, helps to normalize the balance in the pro-oxidant-antioxidant system, restores blood parameters, and also activates regenerative processes in the bone marrow. It was established that intraperitoneal administration of micro-particles of carbon in rats with EDID at a dose of 1.4 mg/ml twice a week for 4 weeks leads to restoration of antioxidant protection parameters, reduces the content of oxidatively modified proteins, secondary products of lipid peroxidation and diene conjugates in the blood and internal organs, restores blood and biochemical parameters, reduces the level of CPK and troponin by 2.2 and 2.6 times, respectively, and also leads to a significant increase in the number of MEC and an increase in their percentage content, which indicates for active regenerative processes in the bone marrow under the influence of carbon nanoparticles. Product Description popup.authors Bardakhivs'ka Kvitoslava I. Herashchenko Bohdan Ivanovych Klymchuk Dmytro O Korneeva Liudmyla M. Korotich Valentyna G. Maslenny Vitalii M. Paziuk Liubov M. Sarnatskaya Veronika V. Sidorenko Olexii S. Snezhkova Elizaveta O. popup.nrat_date 2023-02-12 Close