Search academic texts

Information × Registration Number 0223U002295, 0118U005468 , R & D reports Title The role of remodeling markers of bone tissue in the formation of the degree of malignancy of the most common hormone-dependent tumors popup.stage_title Head Lukianova Nataliia Yu., Доктор біологічних наукChekhun Vasyl Fedorovych, Доктор медичних наук Registration Date 14-02-2023 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2 It has been established that the increase in the expression of OPN and ON in the tissue of BC and PCa of high malignancy degree is associated with an imbalance of pro- and anti-inflammatory cytokines (IL6 and IL10) in the blood of patients. Indicators of OPN and ON expression in BC and PCa cells directly correlate with the level of IL-6 in the blood of patients with BC and PCa and inversely correlate with IL10. It was shown that increased expression of OPN and ON was observed in neoplasms with high levels of N-cadherin expression, as well as moderate and low levels of E-cadherin expression. It was demonstrated that in patients with breast cancer, whose neoplasms were characterized by an increased level of expression of OPN/ON and N-cadherin, as well as a low level of E-cadherin, the overall survival rates were 18.0% and 12.0% lower compared to patients, neoplasms of which were characterized by low levels of OPN/ON and N-cadherin expression, as well as high levels of E-cadherin. A significant decrease in the two-year recurrence-free survival rate by 15.0 and 19.0% was found in patients with PCa with a high level of expression of OPN/ON and N-cadherin and a low level of E-cadherin in the tumor tissue. Thus, dysregulation of the expression of markers of bone tissue remodeling in the cells of the most common hormone-dependent neoplasms of a high degree of malignancy causes a significant imbalance of pro- and anti-inflammatory cytokines (IL6 and IL10) in the blood of patients and is associated with a decrease in the adhesive properties of malignantly transformed cells. Product Description popup.authors Borikun Tetiana V. Virych Petro A. Zadvornyi Taras V. Kunska Lyubov M. Mushii Oleksandr M Nalieskina Lesia A. Pavlova Anna O Todor Igor M. popup.nrat_date 2023-02-14 Close