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Information × Registration Number 0223U002351, 0119U103092 , R & D reports Title To study the peculiarities of retinoblastoma regression patterns, the main complications of solvage and liquiding eye treatment and to develop methods of their elimination popup.stage_title Head Bobrova Nadiya F., Доктор медичних наук Registration Date 15-02-2023 Organization State Institution "The Filatov Institute of Eye Disease and Tissue Therapy of NAMS of Ukraine" popup.description2 Case study: 187 children (217 eyes) with retinoblastoma (RB). Purpose: To study study the retinoblastoma regression features, the main complications of salvage (primary polychemotherapy - intravitreal + systemic) and liquidation (using high-frequency electrical digestion of biological tissues) eye therapy and to develop methods of their elimination. The results and novelty. Method of intravitreal cytostatic (melphalan) injection for retinoblastoma treatment in children, which ensures the regression of the intraocular tumor and prevents the reflux of the vitreal body which allows to increase the intervention ablasticity has been elaborated (Patent of Ukraine No. 144595 dated 12.10.2020. Bull. No. 19. 2020). Elaborated method for high-risk and recurrent RB treatment, which is combined with intravitreal melphalan chemotherapy in increased doses of 20 or 30 mcg in combination with systemic chemoreductation allows to accelerate the regressive changes of large tumors (Certificate on copyright No. 101681 issued 04.01.2021). A new method of consolidating therapy of RB of pre-equatorial localization has been developed, which consists of transscleral cryodestruction and intravitreal administration of melphalan, which potentiates the effect of each of them (Copyright Certificate No. 102681 dated 02.18.2021). A new method of consolidating therapy of solid RB - combination of intravitreal chemotherapy with brachytherapy has been developed, which allows for the maximum therapeutic effect on tumors. (Copyright certificate No. 111039 dated January 14, 2022). The developed original method of radiation cataract surgery prevents the dissemination of RB, tumor activation and ensures the restoration of visual axis transparency (Copyright certificate No. 111996 dated February 21, 2022). Product Description popup.authors Boiko Nadiya O. Bratishka Oleksandr Yu Vit Valeriy V. Volkova Ludmila F. Gavronska Nataliya F. Dembovetska Ganna M Molchanuk Natalia I. Romanova Tetiana A. Sorochinska Tetiana A Suhodoeva Lina O Tronina Svitlana F Shved Ganna V popup.nrat_date 2023-02-15 Close