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Information × Registration Number 0223U002363, 0121U111449 , R & D reports Title To investigate the patterns of expression of cellular and molecular markers by lymphocytes and tumor cells to assess violations of antitumor immunity in patients with acute myeloid leukemia. popup.stage_title Head Hordiienko Alla I., Доктор біологічних наук Registration Date 15-02-2023 Organization State Institution "Institute of Hematology and Transfusiology of the National Academy of Medical Sciences of Ukraine" popup.description2  Object: 17 patients with acute myeloid leukemia in the first acute period. Methods: general clinical, immunophenotyping, cytological, cytogenetic, statistical. The aim is to investigate the intensity of expression of the CD28 receptor on CD3+ T-lymphocytes and costimulatory molecules of the B7 family (B7.1/CD80, B7.2/CD86) on a clone of tumor cells and monocytes. It was shown that the low level of intensity of expression of B7 family co-stimulatory molecules (B7.1/CD80, B7.2/CD86) by peripheral blood tumor cells with an immunophenotypic profile CD34+, CD117+, CD33+ suppresses antitumor immune responses in patients with acute myeloid leukemia. The obtained data indicate a violation of antitumor homeostasis and an increase in tumor progression. Medical and social effect. Medicine. Product Description popup.authors Aladieva Olena M Hordiienko Alla Ivanivna Tretyak Nataliia Mykolaivna popup.nrat_date 2023-02-15 Close