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Information × Registration Number 0223U002420, 0119U103909 , R & D reports Title Molecular and genetic mechanisms of hypoxia influence on inflammation and metabolic disorders popup.stage_title Head Portnychenko Alla H., Доктор медичних наук Registration Date 18-02-2023 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2 In experimental studies on rats, the pathogenetic and compensatory mechanisms of the development of LPS-induced inflammatory process were characterized, and significant changes in breathing patterns, gas exchange and energy metabolism with the development of a hypometabolic state and oxidative stress, and participation of IGF-1/PI3K/Akt-dependent pathways and miRNA-34a in mediating proapoptotic and reparative processes has been established. It is shown that the granular endoplasmic reticulum can take a part in reparative processes regarding structurally damaged mitochondria or organelles in a state of overload. The dependence of the mechanisms of cellular and metabolic protection, in particular the dynamics of mitochondria and their structural changes, manifestations of endothelial dysfunction, activation of ribosomes, the development of apoptosis in the myocardium, lungs, and liver during severe hypoxia and hypoxic preconditioning, on the activation of signaling pathways dependent on phosphatidylinositol-3-kinase has been demonstrated. Product Description popup.authors Aliyev Rufat B. Babicheva Victoria V. Bakunovsky Оlexander M. Baranovska Irina O. Bratus Larysa V. Vasylenko Maryna I. Harmatina Olha I. Gonchar Olga Olga O. Dubova Maria H. Zavgorodniy Mykola O. Kozlovskaya Maria G. Korolʹova Yelyzaveta V. Mankovs’ka Iryna M. Moiseenko Yevhen V. Ponomareva Irina V. Portnichenko Volodymyr I. Putiy Yuliya V. Rozova Kateryna V. Serebrovska Tetyana V. Sidorenko Alla M. Tymoshenko Kateryna R. Topchanyuk Lubomir Y. Tsapenko Petro K. Shapovalova Anastasiia popup.nrat_date 2023-02-18 Close