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Information × Registration Number 0223U002604, 0120U101345 , R & D reports Title Improving the diagnostic and treatment of patients with comorbidity pulmonary tuberculosis and diabetes popup.stage_title Head Todoriko Liliia D., Доктор медичних наук Registration Date 24-02-2023 Organization Bukovinian State Medical University popup.description2  Our results showed that 39.9% of TB patients have a mutation in the promoter zone of GST genes; 64.8% of patients are carriers of the pathological 0/0 genotype of the GSTM1 gene in the haplotype; the combination of a homozygous mutation of the GSTT1 0/0 gene occurs in almost 27.7% of the examined. The study used that 4.2% of pulmonary TB patients are carriers of pathological genotypes of both GST gene isoforms. In the presence of a mutation of the GSTM1 isoform (GSTT1+ / GSTM1 0/0), adverse reactions are likely to be registered more often (p=0.04). Toxic-allergic side reactions were observed in all carriers of mutant genotypes for both genes (GSTT1 0/0 / GSTM1 0/0). Improving diagnosis of TB/DM comorbidity and assessment of pathogenetic features of syntropia, made it possible to assess the prognostic impact of diabetes on the frequency and development of resistant tuberculosis and to predict the main risks of pharmacological correction of both diseases. Product Description popup.authors Ieremenchuk Inga V. Pidverbetska Оlena V. Semyaniv Ihor O. Slyvka Viktor I. popup.nrat_date 2023-02-24 Close