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Information × Registration Number 0223U002829, 0120U100711 , R & D reports Title Experimental study of the reproductive, adaptive and behavioral effects of prenatal endocrine disruptors popup.stage_title Head Reznikov Oleksandr H., Доктор медичних наук Registration Date 09-03-2023 Organization State Institute "V.P. Komissarenko Institute Of Endocrinology And Metabolism of The National Academy of Medical Science of Ukraine" popup.description2  Subject: Neuroendocrine regulation of reproduction and adaptation systems after prenatal exposure to ibuprofen in male rats and dibutyl phthalate and bisphenol A in females. The effects of ibuprofen (60 mg/kg), bisphenol A (BPA, 25 μg/kg), and dibutyl phthalate (DBP, 100 mg/kg) administered to Wistar rats from 15 to 21 days of pregnancy on sexual development, reproductive organs, the morphology of sex-dimorphic area of the brain, hormonal profile, stress-reactivity and male and female sexual behavior of the offspring of the first generation in adulthood were studied. Estradiol diacetate (Е2D) was used as a positive control to study the effects of BPA. In adult males, exposed to ibuprofen, a weakening of copulatory behavior was found without feminization of sexual behavior, as well as oxidative stress in testicles and ventral prostate. In female rats, prenatal exposure to BPA or Е2D decreased estradiol levels in blood plasma. In the positive control group, the number of primary follicles in the ovaries decreased, and in the animals of the BPA group, degeneration of the epithelium in the follicles was observed. Masculinization of sexual behavior, which was not accompanied by its defeminization, was observed in females of Е2D and BPA groups. Morphology of the sex-dimorphic medial preoptic nucleus of the brain correlates with masculinization of sexual behavior in females. Puberty was accelerated in females whose mothers were exposed to DBP. Prenatal use of DBP increased estradiol levels in adult females, and there was a clear tendency to decrease the number of follicles. Administration of DBP to rats during the last week of pregnancy can lead to masculinization of sexual behavior in female offspring but is not accompanied by its defeminization. The results of the work indicate the negative impact of endocrine disruptors on the prenatal programming of the neuroendocrine system of reproduction. Product Description popup.authors Lymareva Anna A Perchyk Inna Polyakova Lubov Sachynska Olga V Falyush Oksana A popup.nrat_date 2023-03-09 Close