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Information × Registration Number 0223U002844, 0118U000216 , R & D reports Title Mechanisms of the functioning of interferon and cytokine systems for infectious and noninfectious pathological conditions, the course of which is accompanied by the development of inflammatory response of the organism popup.stage_title Head Spivak Mykola Ya, Registration Date 13-03-2023 Organization Institute of Microbiology and Virology named after D. K. Zabolotny of the National Academy of Sciences of Ukraine popup.description2  It was established that the detection of IgG antibodies to the simplex virus in sick women herpes-1 and -2 with determination of their avidity index, as well as product research cytokines, primarily interferon, the number of T cells and their individual subpopulations, it is advisable to use natural killer cells in complex diagnostics precancerous diseases of the cervix. The properties of 5 strains of lactobacilli and bifidobacteria are described in detail, as well as nanoparticles of cerium dioxide. Developed and/or modified four models of infectious and inflammatory processes in vivo on BALB/c, SBA and mice Wistar rats, namely, a strain-induced staphylococcal vaginitis model S. aureus 8325-4, a model of diet-induced chronic inflammation obesity, a model of diclofenac-induced liver injury and a model streptozotocin-induced diabetes. On the above models as well on the model of the physiological norm, the effect of bacterial genera was determined Lactobacillus, Bifidobacterium, as well as nanoparticles of cerium dioxide on the spectrum microbiota of different cavities, biochemical indicators, physiological state of internal organs and the state of immunity. A nanobiocomposite based on recombinant necrosis factor was created tumor-α and recombinant tumor necrosis factor-α-thymosin-α1 with CeO2 nanoparticles, the optimal conditions for obtaining nanocomplexes have been worked out and proved the ability of cerium dioxide nanoparticles to increase the activity of both preparations of recombinant tumor necrosis factor-α in the in vitro system. It is shown that the use of Vaxigrip Inactivated Influenza Vaccine (split virion) modified by unstabilized CeO2 nanoparticles is more effective than using the original (unmodified) vaccine and modified with citrate-stabilized CeO2 nanoparticles, as well as is accompanied by significant and long-term activation of the humoral link of the immune system answers Product Description popup.authors Babenko Lidia P. Bohorad-Kobelska Olena Boiko Natalya V Bubnov Rostyslav V. Vasyliuk Olha M. Ganova Larysa A. Demchenko Oleksandr A. Dubova Iryna V. Esaulova Valentyna Zholobak Nadiia M. Zholudenko Evgenia R. Zakharchenko Natalia St. Korol Zvitana Kryvtsova Marina V. Lazarenko Liudmyla M. Osinniy Ivan Sabirova Tatiana Jurivna Spivak Mykola Ya. Surikhina Olha Tymoshok Nataliya O Umarova Oksana Shydlovska Olga Shcherbakov Оlecsandr B. popup.nrat_date 2023-03-13 Close