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Information × Registration Number 0223U003189, 0122U001510 , R & D reports Title Induced changes of the spectrum of biologically active compounds and accumulation of recombinant proteins in genetically engineered plants popup.stage_title Head Kuchuk Mykola V., д.б.н. Registration Date 04-04-2023 Organization Institute of Cell Biology and Genetic Engineering of the National Academy of Sciences of Ukraine popup.description2 In our work we developed and implemented a method of increasing the yield of antioxidant and anti-inflammatory compounds in pharmaceutical raw materials of medicinal chamomile by means of pre-sowing X-ray irradiation of seeds in doses of 5-30 Gy. The use of this method demonstrates an increase of the yield of chamomile inflorescences when exposed to 15 Gy, an increase of the content of antioxidants up to 30% when exposed to 5-10 Gy, and a 20% increase in the specific content of chamazulene when exposed to 15 Gy. Magnetic nanoparticles were obtained by the method of "green" synthesis from a mixture of FeCl3/FeSO4/CoCl2 salts. The obtained results provide a new insight into the features of the "green" synthesis of magnetic nanoparticles and the possibility of their application in adsorption technologies. The antimicrobial activity of plant extracts of the T1-T2 generations of transgenic mizuna and lettuce plants expressing colicin M gene was confirmed against E. coli strain DH10B, as well as several pathogenic and multiresistant strains of E. coli. The biological activity of recombinant interferon α-2b synthesized in transgenic tomatoes was also confirmed. Data from our experiment on the survival of mice after infection with the BVS virus confirmed the positive effect of human interferon on the course of a systemic viral disease in an unrelated species. Therefore, both medicine and veterinary medicine may have a demand for this interferon for the prevention and treatment of diseases. Product Description popup.authors Belokurova Valeriia B. Bulko Olga V. Zhuk Vladyslav V. Kravets Оleхandra P. Kuchuk Mykola V. Litvinov Sergiy V. Lystvan Kateryna V. Matvieieva Nadiya A. Pchelovska Svitlana A. Rudas Volodymyr А. Sakada Volodymyr I. Symonenko Yurij V. Sokolova Daryna O. Shylina Yuliia V. Shcherbаk Nаtаliia L. popup.nrat_date 2023-04-04 Close