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Information × Registration Number 0223U003213, 0122U000770 , R & D reports Title Determination of osteoconductive and osteoinductive properties of polymer-hydroxyapatite biodegradable scaffolds popup.stage_title Head Oleshko Oleksandr M., Кандидат медичних наук Registration Date 05-04-2023 Organization Sumy State University popup.description2  The object of research is the processes of 3D printing of three-dimensional biodegradable polymer scaffolds. The subject of research is the structure and physico-chemical and biological properties of polymer-nano-hydroxyapatite scaffolds obtained by the 3D-printing method with nanoparticles of silver and zinc oxide. The purpose of the work is to establish the general laws of creating three-dimensional polymer nanohydroxyapatite scaffolds in order to control resorption processes in biological conditions and the biocompatibility of implants modified by composition and structure, as well as their antibacterial properties, due to the inclusion of nanoparticles of silver and zinc oxide. To achieve the goal, the following tasks were defined: 1. Theoretical analysis of the formation mechanisms of biopolymer nanohydroxyapatite scaffolds; 2. Development of an algorithm for compiling a mathematical model for the creation of biopolymer scaffolds, which is based on the method of designing three-dimensional objects and statistical analysis, which takes into account the parameters of the 3D print process.; 3. Development of a laboratory technique for creating biopolymer scaffolds with nanoparticles of silver and zinc oxide, taking into account the variability of 3D print parameters.; 4. 3D printing of biopolymer nanohydroxyapatite scaffolds with the addition of silver and zinc oxide nanoparticles. Determination of 3D printing parameters (temperature, fiber diameter, metric parameters of pores and scaffold thickness) depending on PCL/PLA ratio and nanohydroxyapatite concentration. 5. Data summarizing the results of the study from the point of view of the influence of the ratio of polycaprolactone (PCL) / polylactic acid (PLA) and the concentration of nanohydroxyapatite, 3D printing parameters (temperature, fiber diameter, metric parameters of the pores and thickness of the scaffolds), as well as the concentration of silver nanoparticles and of zinc oxide on the microstructure, me Product Description popup.authors Berladir Kristina V. Hapchenko Andrii V. Deineka Volodymyr M. Dryhval Bohdan O. Dudko Yuliia S. Oleshko Oleksandr M. Oleshko Tetiana B. popup.nrat_date 2023-04-05 Close