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Information × Registration Number 0223U003241, 0119U101882 , R & D reports Title Materials created by structural modification of mixtures of hydrophobic and hydrophilic components, their properties and methods of use popup.stage_title Head Turov Volodymyr V., Доктор хімічних наук Registration Date 06-04-2023 Organization Chuiko Institute of Surface Chemistry of NAS of Ukraine popup.description2  Based on methylsilica and protein molecules - lectin and gelatin, composite systems with certain cytotoxic (AM1/lectin) and adsorption (AM1/gelatin) activity have been developed. For both types of composites, the mechanisms of binding water to the surface and methods of transferring hydrophobic materials into the aqueous environment were investigated. The state of interphase water in air, organic and acidic environments was studied. It was established that the presence of a hydrophobic component in composites stabilizes surface water in a weakly associated state, when a significant part of water molecules does not form hydrogen bonds. A liquid hydrophobic medium enhances this effect, and a strong acid (trifluoroacetic acid) added to it promotes the transition of water into a strongly associated state. It is shown that the redistribution of water in the interparticle gaps of AM1 with protein molecules immobilized on their surface changes under the influence of mechanical loads. Mechanically activated samples are characterized by the possibility of water penetration into the gaps between the primary particles of methyl silica. For the AM1/gelatin composite, a significant adsorption activity in the aqueous medium in relation to molecules of average molecular weight was found. AM1/lectin composites were submitted to the Institute of Oncology to study their cytotoxic activity. Product Description popup.authors Golovan Alina P. Zrol Lina V. Kartel' Mykola T. Klymenko Nataliya Yu. Krupska Tetiana Vasylivna Novikova Olena A. popup.nrat_date 2023-04-06 Close