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Information × Registration Number 0223U003410, 0118U002405 , R & D reports Title Investigation of properties of N-alkoxyderivatives of trivalent nitrogen atom in multicomponent isocyanide reactions popup.stage_title Head Tsyhankov Oleksandr V., Доктор хімічних наук Registration Date 27-04-2023 Organization National Technical University "Kharkiv Polytechnic Institute" popup.description2  The objects of research are multicomponent reactions of the Döbner, Hröbke, and Ugy types involving aminoazoles and aromatic aldehydes, as well as their combinations. The subject of research is aromatic amines, N-alkoxyamines, 5-amino-3-arylpyrazoles, aromatic aldehydes, derivatives of 3,5-dimethyl-1H-pyrrole-2-carboxylic acid. The main goal of the project is the development of effective synthetic approaches (high-tech, as universal as possible ). , simple and environmentally safe) to increase the molecular diversity of organic compounds, including through the use in isocyanide multicomponent reactions of purposefully functionalized starting reagents for further controlled postcyclization of the products of such interactions. Research methods - organic synthesis, a set of chemical and physicochemical research methods, including 1H and 13C NMR spectroscopy, IR spectroscopy, mass spectrometry. Practical value and scientific news. The work expands the molecular diversity of heterocyclic compounds of various structures, develops approaches and methods for their synthesis, and contains about 50 new representatives of nitrogen-containing organic compounds belonging to different classes. Synthesized new organic compounds combine several pharmacophore fragments in their structure and can be used in the synthesis of new generation drugs. Studies were conducted to determine the biological activity of the obtained azomethines and the antibacterial activity was evaluated on reference test cultures and clinical strains. It was found that all compounds are effective only against gram-positive bacteria, i.e. not broad-spectrum. But there is an assumption that certain compounds have cytotoxicity and are promising for modification and further research on antitumor activity. Product Description popup.authors Neskorozhena Galyna D. Tsyhankov Oleksandr popup.nrat_date 2023-04-27 Close