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Information × Registration Number 0223U003691, 0120U000416 , R & D reports Title Pharmaco-mathematical analysis of the results of the screening of derivatives of mono-, di-, and tricyclic nitrogen-containing heterocycles with analgetic and anti-inflammatory activity for drug design new bioactive compounds popup.stage_title Head Demchenko Anatoliy М., Доктор фармацевтичних наукSeredinskaya Natalia Mykolayivna, Доктор медичних наук Registration Date 15-06-2023 Organization Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine popup.description2 An in silico analysis of the active binding sites of arachidonic acid, the reference drug ndga, and new BARs with the biotarget of LOG-5, known NSAIDs, and new BARs with the biotargets of COX-1, COX-2 was performed. New BARs in the series of tetrahydroazepine, triazolo-azepine, imidazo-azepine, imidazo[1,2-a]azepin-3-one and triazacyclopenta[cd]-azulene were synthesized, and their pharmacological testing was carried out. Peculiarities of the relationship "structure - activity" as an element of the system for evaluating the biological effects of physiologically active substances in medical technologies aimed at the search for new BARs were studied. According to the results of pharmacological testing, the following showed significant analgesic and anti-inflammatory activity: tetrahydroazepine 2518 (-80.04 and -43.54) %, imidazo-azepines 2614, 2615 ( (-39.04; -36.04 and -84.68; - 68.79) %, triazolo-triazine 4774 (-60.81 and -31.20) % in comparison with ketorolac and diclofenac (-85.89 and -44.37) %, respectively.  Product Description popup.authors Bobkova Liudmyla S. Lukianchuk Viktor D. Yadlovskyi Oleh Ye. popup.nrat_date 2023-06-15 Close