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Information × Registration Number 0223U003762, 0122U201961 , R & D reports Title Complex oxide phosphates as the basis of effective functional materials for different application popup.stage_title Head Strutynska Nataliia Yu., Доктор хімічних наук Registration Date 29-06-2023 Organization Strutynska Nataliia Yu. popup.description2  The conditions for obtaining biphasic calcium phosphates doped with Mg2+ or Zn2+ cations (from 2 to 9wt%) have been established. Ways of regulating the content of the phase based on -Са3(РО4)2 (increase from 20 to 35 wt.%) in the composition of biphasic composites by changing the Zn/Ca molar ratio from 0.04 to 0.17 in the initial solution are shown. This way in the following is important for regulating the resorption characteristics of synthetic biomaterials. Evaluation of the cytotoxicity of the synthesized materials revealed their safety at amounts of up to 5 mg/ml for the sample based on the apatite-type phase (up to 90 wt%), while the sample based on the whitlockite-type phase (90 wt%) promoted cell proliferation. Hybrid compositions based on the synthesized whitlockite-related sodium-containing calcium phosphate with Alginate (20, 30 or 50 wt.%) and C60 fullerene (2 or 5 wt.%) were developed. It was established that the addition of Alginate (20 wt.%) and C60 (5 wt.%) to phosphate improves mechanical properties (increase in compressive strength by 2 times and Young's modulus by 20%) and antibacterial activity against a pathogenic strain (a tenfold decrease in the survival of the strain S. aureus). The obtained results are important in the development of modern biomaterials based on modified calcium phosphates, as well as their biphasic compositions for medical use. Product Description popup.authors popup.nrat_date 2023-06-29 Close