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Information × Registration Number 0223U003972, 0120U103997 , R & D reports Title Measurement of redox potentials (ORP) of N-substituted p-quinone imines by direct potentiometry. popup.stage_title Head Avdeenko Anatoly P., Кандидат хімічних наук Registration Date 02-08-2023 Organization Donbass State Engineering Academy popup.description2  Object of research: N-arylsulfonylbenz(methyl)imidoyl-1,4-benzoquinone monoimines. Purpose: to develop a method for determining the redox potentials of N-arylsulfonylbenz(methyl)imidoyl-1,4-benzoquinone monoimines and their measurement. Methods: organic synthesis, physicochemical methods of research of organic compounds: IR, 1H NMR, 13C NMR spectroscopy, elemental analysis, direct potentiometry. Results: N-arylsulfonylbenz(methyl)imidoyl-1,4-benzoquinone monoimines have been synthesized. Their redox potentials (ORPs) were measured by direct potentiometry. Their ORPs were close to the ORP of redox pairs, which were measured by potentiometric titration of 4-arylsulfonylbenz(methyl)imidoyl-aminophenols with lead tetraacetate in a 0.5 M solution of sodium acetate in glacial ethanoic acid. It was experimentally shown that there is a relationship between the nature of the substituent in the para-position of the aryl fragment of N-arylsulfonylbenz(methyl)imidoyl-1,4-benzoquinone monoimines and their ORP: with increasing electron-accepting properties of the substituent the ORP of quinone imine increases. Efficacy: The results provide important information for predicting the behavior of these quinone imines in different biological systems when using their reduced forms as drugs. This allows to purposefully search for new drugs based on similar structures, as well as search for the most rational ways of their synthesis based on information about their redox properties. Product Description popup.authors Avdieienko Anatolii P. Konovalova Svetlana A. Menafova Yuliya V. Marchenko Inna L. Santalova Anna O Kholmovoi Yuri P. Yusina Anna L. popup.nrat_date 2023-08-02 Close