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Registration Number

0223U004089, 0120U104154 , R & D reports

Title

Endothelial dysfunction, hypercoagulation and microvascular thrombosis in COVID-19: risk assessment, pathogenesis and diagnosis

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Head

Korda Mykhailo M, д.мед.н.

Registration Date

30-08-2023

Organization

I. Horbachevsky Ternopil State Medical University

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 Report on the GDR: 42 pp., 46 sources, 8 tables, 2 figures. Endothelial dysfunction, COVID-19, recovery period, SARS-CoV-2, ACE2, adhesion molecules, endocan, endothelin-1, comorbidity. The object of the study is the pathogenesis of endothelial dysfunction, hypercoagulation and microvascular thrombosis in patients who have become ill with COVID-19. The purpose of the work is to establish the molecular mechanisms of the development of endothelial dysfunction, hypercoagulation and vascular thrombosis in persons who have contracted COVID-19 of varying degrees of severity, through a comprehensive study of the production of vasorelaxing and vasoconstrictor factors by endotheliocytes, the degree of damage to the vessel walls, the functional state of the endothelium, indicators characterizing the presence of coagulopathy and thrombophilia, parameters of the intensity of oxidative stress and, as a result, the development of recommendations for risk assessment and prevention and prognostic and diagnostic criteria for the development of thrombosis and endothelial dysfunction in patients with COVID-19. Research methods - clinical, biochemical, immunoenzymatic, instrumental, mathematical and statistical.

Product Description

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2023-08-30