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Information × Registration Number 0223U004091, 0121U100305 , R & D reports Title Endothelial dysfunction, hypercoagulation and microvascular thrombosis in COVID-19: implications for risk assessment, pathogenesis, and diagnosis popup.stage_title Head Korda Mykhailo M., Доктор медичних наук Registration Date 30-08-2023 Organization Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine popup.description2  Report on the GDR: 42 pp., 46 sources, 8 tables, 2 figures. Endothelial dysfunction, COVID-19, recovery period, SARS-CoV-2, ACE2, adhesion molecules, endocan, endothelin-1, comorbidity. The object of the study is the pathogenesis of endothelial dysfunction, hypercoagulation and microvascular thrombosis in patients who have become ill with COVID-19. The purpose of the work is to establish the molecular mechanisms of the development of endothelial dysfunction, hypercoagulation and vascular thrombosis in persons who have contracted COVID-19 of varying degrees of severity, through a comprehensive study of the production of vasorelaxing and vasoconstrictor factors by endotheliocytes, the degree of damage to the vessel walls, the functional state of the endothelium, indicators characterizing the presence of coagulopathy and thrombophilia, parameters of the intensity of oxidative stress and, as a result, the development of recommendations for risk assessment and prevention and prognostic and diagnostic criteria for the development of thrombosis and endothelial dysfunction in patients with COVID-19. Research methods - clinical, biochemical, immunoenzymatic, instrumental, mathematical and statistical. Product Description popup.authors popup.nrat_date 2023-08-30 Close