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Information × Registration Number 0223U004868, 0123U102749 , R & D reports Title Hybrid nanosystems for photoimmunotherapy in the optical-X-ray energy range popup.stage_title Head Yashchuk Valerii M., Доктор фізико-математичних наук Registration Date 06-12-2023 Organization Taras Shevchenko National University of Kyiv popup.description2 Research object – chitosan, polystyrene, hafnium oxide, DNA, chlorin e6, berberine, fullerene, nanoparticles of fullerene-containing nanosilica with and without incorporated palladium compounds, model membranes. Subject of work – formation of nanosystems "heavy atom / organic matrix / photosensitizer / chitosan", interactions between components and electronic processes in these nanosystems, and their interaction with model membranes. Purpose of work – establishing and studying the physical mechanisms of photo / X-ray dynamic action, design of photo / X-ray-excited nanosystems for sensitization of reactive oxygen species with improved membrane permeability and combined photo / X-ray dynamic and immunotherapeutic action, and the possibility of X-ray and optical visualization. Research methods – measurement of absorption, photo- and X-ray luminescence spectra of nanosystems in the presence of chitosan and model membranes, and generation of luminescence of singlet oxygen upon their excitation. Results and novelty – Formation and electronic processes in "heavy atom / organic matrix / photosensitizer / chitosan" nanosystems and their interaction with model membranes were studied. The formation of the nanosystem "hafnium oxide nanoparticles / polystyrene nanoparticles / chlorin e6 / chitosan", generation of singlet oxygen by this system, and a noticeable increase in the absorption of X-rays by the system due to a small amount of hafnium oxide nanoparticles in it are shown. This nanosystem is proposed for the development on its basis of nanosystems for Xray dynamic therapy. Product Description popup.authors Gryn Dmytro V. Degoda Volodymyr Ya. Losytskyy Mykhaylo Yu. Navozenko Oleksandr M. Podust Galyna P. popup.nrat_date 2023-12-06 Close