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Information × Registration Number 0223U004888, 0123U102735 , R & D reports Title Plasmon hybrid nanosystems "metal-polymer-fluorophore" with enhanced optical response for photonics and biomedical applications popup.stage_title Head Yeshchenko Oleh А., Доктор фізико-математичних наук Registration Date 07-12-2023 Organization Taras Shevchenko National University of Kyiv popup.description2 Research object: hybrid nanosystems based on polymer matrices, metal nanoparticles (NPs) and fluorophores-dyes; thermosensitive polymers; photosensitive polymers. Research subject: processes of interaction and binding of components of hybrid nanosystems; the effect of plasmon enhancement on the optical properties and biological activity of hybrid nanosystems; thermo- and photoinduced phase transitions in hybrid nanosystems; electronic processes in photosensitive polymers based on azo-containing derivatives with quinoline and thiazole fragments. Purpose of work: the creation of new multi-component hybrid nanosystems "metal/polymer/fluorophore", in particular thermo- and photosensitive ones, and the use of the phenomenon of plasmon enhancement and mutual potentiation of individual components for effective biomedical applications of such nanosystems and their applications in photonics, synthesis of photoactive polymers for optical switches and fluorescent labels, study of photochemical properties of polymers with azoquinolines and thiazoles fragments. Research methods: transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), dynamic light scattering (DLS), light absorption, photoluminescence (PL), Raman light scattering, measurement of photoinduced birefringence, numerical computer calculations and simulations. Results and novelty: Aggregationally and sedimentationally stable triple hybrid ZnTPP/D-g-PAAan/AuNPs and ZnTPP/D-g-PNIPAM/AuNPs nanosystems were synthesized. It was found that due to significant plasmonic enhancement of photogeneration of chemically highly active singlet oxygen, these nanosystems have high antibacterial photodynamic activity in vitro. The high cytotoxicity of the D-gPAA/ZnO NP hybrid nanosystem against prostate and breast cancer cell lines in vivo was proven. Product Description popup.authors Virych Pavlo A. Virych Petro A. Kuziv Yuliya I. Kutsevol Nataliia V. Smokal Vitalii O. Tomchuk Anastasiia V. Khort Pavlo S. Chumachenko Vasyl A. popup.nrat_date 2023-12-07 Close