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Information × Registration Number 0223U004962, 0123U102767 , R & D reports Title Hippocalcin-dependent regulation of long-term depression at normal conditions and primary dystonia popup.stage_title Head Bilan Pavlo V., Доктор біологічних наук Registration Date 11-12-2023 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  At least 55% of the funds allocated to patients with diabetes in Ukraine are spent for treatment of diabetic complications including painful diabetic neuropathy (PDN), a chronic and often incurable syndrome. Numerous investigations causally link upregulation of T-type Ca2+ channels in peripheral nociceptive neurons to painful symptoms of PDN. Effective clinical interventions for PDN are very limited and already developed approaches are characterized by lack of molecular or cellular target specificity, complicated procedures, insufficient suppression, and a short duration of therapeutic effects. In this project we suggest a novel approach based on implementation of virus-mediated cell-specific delivery of siRNA constructs suppressing T-type Ca2+ channels for simple clinically relevant and long-lasting treating diabetic neuropathic pain. The results of the project will lead to a promising therapeutic strategy to treat PDN. Product Description popup.authors Blaschak Ivan O. Dovgan Olexandr V. Dromaretsky Andriy V. Duzhyy Dmytro E. Kononenko Mykola I. popup.nrat_date 2023-12-11 Close