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Information × Registration Number 0223U005325, 0121U110838 , R & D reports Title To study the liver fibrogenesis deptnding on theprovisijn of vitamin D in children with chonic hepatitis and to improve the methods of their diagnosis and treatment popup.stage_title Head Berezenko Valentyna S., Доктор медичних наук Registration Date 20-12-2023 Organization State institution "Institute of Pediatrics Obstetrics and Gynecology named academic Elena M. Lukyanova National Academy of Medical Sciences of Ukraine" popup.description2  It is set that for children from АЗП, that got the саплементацію vitamin of D on 1 of life concentration 25 (OH) D was higher and risk of breaks more subzero, comparatively with patients in that she was not conducted (62,1 [19,8-114] but 52,4 [24,2-77,6] accordingly, р<0,05;. (ꭓ2 = 4,2, р <0,05). It is well-proven, influence 12 monthly course by the саплементації vitamin of D on the worked out chart on фіброгенез for children from АЗП. Achievement of concentration 25 (OH) D in the serum of blood ≥ of 100 нмоль/л results in the decline of concentration in the serum of blood of hyaluronic acid. It is set that 6 monthly course by the саплементації vitamin of D on the worked out chart for children from ХГВ results in the reliable increase of concentration of 25 (ОН) in 75а a tendency takes place to the decline of indexes of АЛТ. It is well-proven that complex ultrasonic research with the use of 2d - SWE and 2d - SWD it can be applied for the estimation of the stage of fibrosis ≥ of F3 AUC - 0,77 (95І 0,62-0,92) and inflammation of YOKE ≥ of 3 degrees of AUC - 0,75 (95% СІ 0,55-0,90) in fabric of liver in for children from АЗП. Diagnostic criteria are worked out : for the stage of fibrosis of liver ≥ of F3 for children from АЗП optimal index 2d - SWE > 8,9 кПа, for determination of activity of inflammation in the liver ≥ of 3 degrees index 2d - SWD >16,35 m/of сек кГц. It is set that decline of index 2d - SWE in the dynamics of treatment is to предиктором efficiency of therapy for children from АЗП. It is set that method 2d - SWE allows to diagnose the stage of fibrosis of liver ≥ of F2 for children from ХГВ with high exactness (AUC 0,89, 95 0,77-1,0). Efficiency of algorithm of саплементації is worked out and well-proven on the basis of monitoring of концентраціїї 25 (ОН) D in the serum of blood for children from Product Description popup.authors Nezpala Anna V. Dyba Maryna B. Donskoi Borys V. Zadorozhna Tamara D. Kaniovska Valtntina A. Kelykhevich Svitlana M. Lutsenko Iryna R. Mykhailiuk Khrystyna Z. Strizhak Svitlana К. Tkalyk Olena N. popup.nrat_date 2023-12-20 Close