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Information × Registration Number 0223U005355, 0123U103867 , R & D reports Title Development of a novel, nanoparticle-based disinfectant for deactivation of pathogens causing emergent infectious diseases popup.stage_title Head Bielikov Kostiantyn M., Кандидат хімічних наук Registration Date 20-12-2023 Organization State Scientific Institution Scientific and Technological Complex" Institute of Single Crystals "of the National Academy of Sciences of Ukraine popup.description2 The goal of the project is the study of metal and metal oxide nanoparticle effect on the biological models with different levels of organization in order to develop a novel, sustained-release disinfectant. The following primary objectives were addressed: -to develop the synthetic approaches for obtaining metallic and bimetallic nanoparticles (NPs) of Ag, Cu, Fe, Zn/Ag, Fe/Ag, Cu/Ag, stabilized by various polymers; -to determine the influence of NPs synthesis conditions on their properties, including size, morphology, suspension stability, etc.; -to study the bactericidal properties of metal NPs and their optimal compositions on test cultures of mycobacteria and enterobacteria; -to determine the toxicological properties of experimental disinfectant samples on laboratory animals; -to formulate a formula of a disinfectant based on metal NPs. The following key outcomes were obtained: -there were determined the optimal conditions for obtaining stable suspensions of metal NPs based on their composition, including reducers, stabilizers, temperature, and pH; -a method for obtaining binary Cu/Ag NPs through the joint sequential reduction of salts of these metals in an aqueous media with sodium borohydride and ascorbic acid was proposed. This method allows for the production of stable suspensions with nanoparticle sizes ranging from 30-40 nm; -through a screening of the disinfection activity of nanoparticle suspension samples against mycobacteria (M. bovis, M. Avium, M. fortuitum) and enterobacteria (E. coli and S. aureus), three of the most active samples of Cu, Zn/Ag, and Cu/Ag nanoparticles were selected. Based on these, formulations for 4 experimental disinfectant samples were developed; -there were established the toxicological properties of the four experimental disinfectant samples using a laboratory animal model. According to acute toxicity assessment results in rats, these samples were classified as Class VI toxicity and Class IV danger based on the degree of hazard. Product Description popup.authors popup.nrat_date 2023-12-20 Close