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Information × Registration Number 0223U005369, 0123U101863 , R & D reports Title Prediction of bioactivity and creation of modern approaches to the synthesis of heterocyclic compounds for the needs of the pharmaceutical industry. Chapter 2. Development of new QSAR models for activity prediction and synthesis of new chemical compounds of heterocyclic nature as antimicrobial, antiviral and anticancer agents popup.stage_title Head Brovarets Volodymyr S., д.х.н. Registration Date 22-12-2023 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 A number of new QSAR models were built, and their use made it possible to successfully identify a number of azole derivatives as highly active antibacterial agents against the standard strain of E. coli (type ATCC), as well as as potential antiviral agents. Antiviral activity against HCMV in vitro of new sulfonamide derivatives was evaluated. In silico and in vitro results of research on the antibacterial and antiviral potential of a number of 1,3-oxazole, 1,3-thiazole derivatives are promising in the search and construction of new low molecular weight heterocyclic compounds with appropriate structural features and a specific molecular mechanism of action. Experimental study and analysis of five-membered nitrogenous heterocycles as antimicrobial and antiviral agents proved the perspective of further research in the direction of their structural optimization and expansion of the spectrum of biological research. Product Description popup.authors Bagreeva Oksana S. Hodyna Diana M. Golovchenko Oleksandr V. Derev'yanko Kateryna Yu. Zhirnov Viktor V. Zyabrev Volodymyr S. Kachaieva Maryna V. Kovalishyn Vasiliy V. Mityukhin Оleg P. Metelytsia Larisa O. Moskvina Viktoria S. Pilyo Stepan Hr. Panchyshyn Svitlana Ya. Porhun Svitlana V. Severin Oleksandr O. Semenyuta Ivan V. Chumachenko Svitlana A. popup.nrat_date 2023-12-22 Close