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Information × Registration Number 0223U005509, 0119U003574 , R & D reports Title Biopharmaceutical development and clinical trials on the efficacy of potential drugs popup.stage_title Head Zamkovaya Aloyna V., Кандидат біологічних наук Registration Date 25-12-2023 Organization Odessa National Medical University popup.description2 At the third stage, "Study of biological activity. Study of acute toxicity of compounds under study. Development of the technology for the preparation of medicinal products in the conditions of a pharmacy/industrial production" found a difference between the indicators of the concentration of flavonoids - the difference is insignificant (0.7%), and between the indicators of the concentration of GHK reaches 34% in favor of sample 1, the manufacturer of which is LLC "Klyuchi Zdoro" I". It was determined that the difference between the sums of polyphenolic compounds for samples 1 and 2 is 7.14% between the samples. It was found that the content of flavonoids is almost the same and is 27.94% and 29.75% of the total amount of PFS for samples 1 and 2, respectively. The HCC content is 9.25 and 7.36% for samples 1 and 2, respectively. It is shown that for both studied samples, approximately 63% of the amount of PFS is due to the share of unknown polyphenolic compounds. 5 flavonoids and 5 hydroxycinnamic acids were identified in thyme herb samples by HPLC, the main identified compounds were: apigenin-7-O-β-D-glucopyranoside (up to 0.80±0.04%); luteolin-7-O-β-D- glucopyranoside (up to 0.74±0.04%), luteolin (up to 0.70±0.04%), rosmarinic acid (up to 0.34±0.02%), in much smaller quantities: eriocitrin, kaftaric, n-coumaric and ferulic acid were identified. The HPLC method established that the "Keys to Health" thyme herb contains 2.29% flavonoids, and 0.33% hydroxycinnamic acids. A fairly high level of antioxidant activity of thyme herb (manufacturer "Keys to Health") was established, the indicators were 50% at the beginning of exposure, increased to 59% after 15 seconds and, gradually decreasing further, still remained sufficiently pronounced. It was calculated that the rate of the autoxidation reaction of adrenaline in the experimental sample with the addition of creeping thyme extract was 0.0309 oo/min, against the control sample – 0.0509 oo/min, where pure adrenaline was us  Product Description popup.authors Zamkovaya Aloyna Kovpak Alona Fizor Nataliya (Tsisak) Kobernik Alona popup.nrat_date 2023-12-25 Close