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Information × Registration Number 0223U005511, 0121U107518 , R & D reports Title Effective methods for formation of 2-styrylpyrimidines based on 2-(2-hydroxy-2-arylethyl) -2,3-pyrimidin-4(3H)-ones popup.stage_title Head Yavolovskyi Arkadii А., Доктор хімічних наук Registration Date 25-12-2023 Organization Physico-Chemical Institute O. Bogatsky National Academy of Sciences of Ukraine popup.description2 The objects of research are 2-styrylpyrimidines, 2-(β-hydroxyalkyl)-pyrimidin-4(3H)-ones, 2-(2-oxo-2-arylethylsulfanyl)-pyrimidin-4(3H)-ones. The aim of the work is to develop effective methods for the synthesis of 2-styrylpyrimidines, starting from 2-(β-hydroxyalkyl)-pyrimidin-4(3H)-ones. Research methods and equipment: PMR spectroscopy (Varian WXP-500), mass spectrometry (MX 1321), A preparative method for obtaining a series of 2-(β-hydroxyalkyl)-pyrimidin-4(3H)-ones by reduction of 2-(2-oxo-2-arylethylidene)-2,3-dihydropyrimidin-4(1H)-ones was developed. The possibility of desulfurization of 2-(2-oxo-2-arylethylsulfanyl)-pyrimidin-4(3H)-ones in acetic acid was studied. A preparative method for obtaining compounds of a series of (E)-6-R-2-styrylpyrimidin-(4H)-ones by dehydration of 2-(2-hydroxy-2-arylethyl)pyrimidin-4(3H)-ones in orthophosphoric acid at elevated temperature was developed. With the aim of further modification, 4-methylbenzosulfonates were synthesized starting from a series of (E)-6-methyl-2-styrylpyrimidin-(4H)-ones. It was established that during the interaction of (E)-6-R-2-styrylpyrimidine-(4H)-ones with an equimolecular amount of Br2, the main product of the reaction turned out to be (E)-5-bromo-6-R-2-styrylpyrimidine-(4H)-ones. The fact of chemical destruction of experimental samples of (E)-6-R-2-styrylpyrimidine-(4H)-ones under the action of UV radiation was not established. The structure of the compounds obtained for the first time was established using HNMR spectroscopy and mass spectrometry. The developed methods for the synthesis of 2-styrylpyrimidines can significantly simplify the processes of obtaining photosensitive systems of the styrylpyrimidine series with multiphotochromic properties, in particular, with the ability for molecular photoswitching.  Product Description popup.authors Ivanov Yurii E. Gryshchuk Lydiya V. Pluzhnyk-Gladyr Serhiy M. Stepanov Dmytro Ye Chihichin Dmytro G. Yavolovskyi Arkadii А. popup.nrat_date 2023-12-25 Close