Search academic texts

Information × Registration Number 0223U005549, 0121U113811 , R & D reports Title 627. Investigate neurobehavioral comorbidities in chronic drug-resistant epilepsy on the example of electrostimulation and chemical kindling in order to develop pharmacological methods for their correction popup.stage_title Head Godlevsky Leonid S., д.мед.н. Registration Date 25-12-2023 Organization Odessa National Medical University popup.description2  The conducted research is aimed at finding pharmacological agents capable of suppressing the excessive excitability of nervous tissue based on the idea of the direct effects of the drug or its metabolites on the neuron. Such an approach, which today remains universal in neuropharmacology, does not exhaust the existing problems, since to this day the manifestations of epilepsy remain poorly controlled due to the presence of pharmacological resistance to antiepileptic drugs in a significant part of epilepsy patients. The results of the study indicate the strengthening of the anticonvulsant effect of axitinib by pioglitazone in relation to seizures caused by the method of pentylenetetrazole kindling. Taking into account the obtained results of prevention of newly formed microvessels, it should be noted that PPARγ agonists inhibit neoangiogenesis and cause anticonvulsant effects. Rapamycin also inhibits neoangiogenesis and exhibits anticonvulsant activity Product Description popup.authors Yehorenko Olha Volokhova Halyna Godlevsky Leonid Denysenko Oksana Zhumatiy Pavlo Kashchenko Olha Kopova Nadiia Liashenko Svitlana Mandel Oleksandr Marchenko Serhiy Onufryenko Oksana Pervak Mykhailo Ponomarenko Andriy Prybolovets Tetyana Rusakova Mariia Ryabenka Olha Smirnov Igor popup.nrat_date 2023-12-25 Close