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Information × Registration Number 0223U005598, 0121U114601 , R & D reports Title Reaserch title: mechanism of epigenetic disorders of the leading links of bioenergy and nitrogen metabolism in irradiated animals and their offspring popup.stage_title Head Stepanov Hennadii F., к.мед.н. Registration Date 25-12-2023 Organization Odessa National Medical University popup.description2 The role of ionizing radiation in disrupting the bioenergetics of various types of muscle tissue has been studied It has been established that general irradiation of rats in doses of 0.5-4.5 Gy causes irreversible and dose-independent edematous degeneration, intracellular lysis, damage to mitochondria of myocardial endotheliocytes, which may play a role in the development of deterministic, non-stochastic consequences of low-dose radiation. After irradiation, thickened muscle cells with enlarged nuclei appear in the heart muscle, the number of which does not decrease for 6 months, which indicates a violation of nuclear-cytoplasmic relations in myocardial cells. The morphometric characteristics of heart mitochondria also change, the contractile capacity of the myocardium is impaired. Blockades of the legs of the bundle of His, violations of the automatism of the sinus node are noted. In the myocardium of an irradiated organism, the efficiency of oxidative phosphorylation decreases not only in the cytochrome section of the respiratory chain of mitochondria, but also in the conjugation points.   Product Description popup.authors Burdina Ianina Vasylieva Antonina Gridina Inna Dimova Alla Kostina Alina Stepanov Gennadiy Storchylo Olha popup.nrat_date 2023-12-25 Close